Which blood type can be transfused into a patient who has blood type A–?

Answers

Answer 1

Answer:

o negative

Explanation:


Related Questions

Which is the pair of the enzyme activities most significantly affected by glucagon- and insulin-dependent phosphorylation and dephosphorylation of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFKFB)?
a. hexokinas ::::: glucose-6-phosphatase
b. phosphofructokinase ::::: Fructose-1,6-bisphosphatase
c. pyruvate kinase :::::: pyruvate carboxylase
d. glycogen synthase ::::: glycogen phosphorylase
e. None of these

Answers

Answer:

b. Phosphofructokinase;  Fructose-1,6-bisphosphatase

Explanation:

Glucagon is a hormone which functions to initiate gluconeogenesis whwreas insulin functions to initiate glycolysis.

Fructose-2,6-bisphosphate (F26BP) is an allosteric regulator of the glycolytic and gluconeogenic enzymes phosphofructokinase-1 (PFK-1) and fructose-1,6-bisphosphatase (FBPase-1).

It stimulates glycolysis and inhibits gluconeogenesis by binding to its allosteric site on phosphofructokinase-1 reducing its affinity for the allosteric inhibitors ATP and citrate .

It is formed by phosphorylation of fructose-6-phosphate catalyzed by  phosphofructokinase-2 and is broken down by fructose-2,6-bisphosphatase which are two separate enzymatic activities of a single, bifunctional protein (PFK-2/FBPase-2).

Phosphorylation of PFK-2/FBPase-2 due to glucagon release enhances its FBPase-2 activity thereby stimulating gluconeogenesis and inhibiting glycolysis.

Dephosphsorylation of PFK-2/FBPase-2 due to insulin release enhances its PFK-2 activity, thereby stimulating glycolysis and inhibiting gluconeogenesis.

In DNA and RNA, a nitrogen base, sugar, and phosphate groups together are called a

Answers

Answer:

Explanation:

In DNA and RNA, a nitrogenous base, sugar, and phosphate groups together are called a nucleotide.

Mark me as brainliest if u liked my answer

Answer:

nucleotide

In DNA and RNA, a nitrogenous base, sugar, and phosphate groups together are called a nucleotide. This answer has been confirmed as correct and helpful.

Explanation:

Which list below describes a possible path of rain through the water cycle? (2 points) Group of answer choices Evaporation, condensation, precipitation, runoff Runoff, ocean storage, evaporation, condensation Transpiration, condensation, precipitation, runoff Evaporation, precipitation, runoff, lake storage

Answers

Answer:

evaporation,condensation,precipitation,runoff

Answer:Evaporation, condensation, precipitation, runoff

Define feeding of living things ​

Answers

Explanation:

the process by which the organism obtsin their their food is called feeding of living thing.

Answer:

Explanation:

Feeding is the process by which organisms, typically animals, obtain food. Terminology often uses either the suffixes -vore, -vory, -vorous from Latin vorare, meaning "to devour", or -phage, -phagy, -phagous from Greek φαγεῖν (phagein), meaning "to eat".

10 male reproductive organs

Answers

-penis
-scrotum
-testes
-epididymis
-vas deferens
-prostate
-seminal vesicles
-erectile tissue
-perineum
-testosterone

What is the allele frequency?

Answers

Allel frequency, or gene frequency, is the relative frequency of an allele at a particular locus in a population, expressed as a fraction or percentage. Specifically, it is the fraction of all chromosomes in the population that carry that allele

Answer:

Explanation:

Allele frequency is the how often or what's the percentage of a particular allele in a population. Allele is referred to as version of a gene that is located on the chromosome.

For example, a gene causing death in rats might have alleles, W and w. Each would be a separate allele and the frequency would be how often or what's the percentage of W or w that is present in the population.

Suppose we are trying to find frequency of W or w allele in a population then the formula is

Allele Frequency = [# of copies of certain allele (either W or w)] / [Total number of W and w alleles]

Now suppose we have 4 WW and 2 ww in a population.

First we count up W allele then we have (4 * 2)= 8 W (we multiplied by 2 because each organism has WW, 4 WW is short of of writing WW , WW, WW, WW)Same concept for 2ww, we have total w = 2 * 2 = 4w

Total alleles = W + w = 8 +4 =12

Allele Frequency for W = 8 / 12 = 66.67%

Allle Frequency for w = 4 / 12 = 33.33%

Hope this helps!

In many states, the legal limit for all bacteria present in pasteurized milk is not to exceed 20,000 CFU/mL. You have been away on vacation and left an unopened plastic jug of milk in your refrigerator. The "Sell By" date was three days ago. Instead of throwing it out, you decide to test it using your eScience Microbiology Kit. Here are your results for a "countable" plate in your serial dilutions: 186 colonies on a plate where the dilution factor was 1 x 10-4 and the volume that you plated was 1 mL. (20 points)
a. How many bacteria are present in 1 mL of this milk?
b. Is this milk safe to drink by Public Health standards?

Answers

Answer:

a. The formula for finding the number of colonies in a given volume is,  

CFU/ml, here CFU is the colony forming units or the number of colonies formed in a volume plated in ml × dilution

The dilution factor given in the question is 1 × 10⁻⁴ and the number of colonies given is 186. Therefore, the number of bacteria present in the given 1 ml of the milk is,  

CFU/ ml = 186 / 1 × 10⁻⁴ = 186 × 10⁴.  

Hence, the concentration of bacteria in the milk is 186 × 10⁴ CFU/ml.  

b) The limit of the bacterial concentration in the pasteurized milk is 20000 CFU/ml, however, it can be seen that the sample of the milk possess more concentration of bacteria than the desired value. Therefore, the milk is not safe to drink by Public Health Standards.  

A particular cell has half as much DNA as some other cells in a mitotically active tissue. The cell in question is most likely in Group of answer choices

Answers

Answer:

This question is incomplete. Group of answer choices are:

A. G1

B. G2

C. Prophase

D. Metaphase

E. Anaphase

The correct answer is A.

Explanation:

The G1 phase (Gap 1 phase) is the period of the cell cycle from the time a cell is born until the S phase begins. When the G1 phase begins (just after the division of the stem cell) the size of the newly originated cell is half of its normal size, and the cell must grow to reach it. For this, in this period, RNA and proteins are actively synthesized. During this period, the cell has only the amount of DNA that it has received from its progenitor and each chromosome is made up of a single chromatid, since DNA replication has not yet occurred.

You are the microbiologist in charge of reading the Gram stain for this case. You observe Gram positive cocci, epithelial cells, and neutrophils. List at least two genera of clinically significant bacteria that are consistent with your observations.

Answers

Answer:

The genera include...

Mycobacterium

Actinomyces.

Explanation:

The genera Actinomyces and mycobacterium show significant observation of gram positive bacteria because they test positive and give a violet or purple color under microscope when the undergo gram staining which is which uses crystal violet due. They are able to retain the violet color due to their posses of thick peptidoglylcan cell wall.

Actinomyces spp. Of the general actinomyces play an important role in soil ecology, and some species are human pathogens that cause diseases.

Mycobacterium genera example is bacilli which is covered with a mycolic acid coat. This waxy coat protects the bacteria from antibiotics, prevents them from destruction and hinder the penetration by Gram stain reagents. They cause different infectious diseases in humans.

A hypothetical Island lies far from any other landmasses. There are many different types of plants, but only one animal, a beetle plant and feed by chewing leaves. Given that the beetle is not exploiting all the resources on the island, which morphologic trigger an adaptive radiation of the beetles?

Answers

Answer:

a mouthpart that can pierce fruits and seeds

Explanation:

An adaptive radiation is a process in which organisms diversify rapidly from an ancestral species into a multitude of new forms. That being said the most likely morphological change that would trigger this would be a mouthpart that can pierce fruits and seeds. This new change would allow the beetles to consume most of the different resources that the island has to offer such as the different types of plants and fruits which were previously inaccessible to the beetles.

Barney gets divorced after his wife finds out that he is having an extramarital affair with another woman. After the divorce, Barney finds it extremely difficult to cope with life as he realizes that he has lost a good partner who always supported him. According to E. Mavis Hetherington's research, Barney would most likely be categorized as a(n)

Answers

The options are missing in this question; here are the options:

According to E. Mavis Hetherington's research, Barney would most likely be categorized as a(n)

A) defeated

B) competent loner

C) enhancer

D) good-enough

The answer to this question is A) defeated

Explanation:

E. Mavis Hetherington is an important Canadian psychologist mainly known for studying divorce and the effects of it. About this, the psychologist proposed divorce is a complex process and has a great impact on those involved. In the case of the spouses, E. Mavis Hetherington proposes four main styles spouses might acquire after divorces such as competent loner, defeated, enhancer, etc.

In the category of defeated this psychologist includes those that do not cope with life after divorce, instead, they experience depression, loneliness, regrets, and other negative feelings, which stop them from thinking positively about the future or adapting to their situation. This category describes Barney because after divorce he feels regretful and depressed; also, he has great difficulty to cope with life or adapt to the situation.

Each statement below describes either the bacteriophage lytic cycle, the bacteriophage lysogenic cycle, or applies to both the lytic and lysogenic cycles. Drag each statement to the correct bin.
1) Phage DNA is replicated along with the bacterial chromosome during cell
2) Phage attaches to host cell Bacterial chromosome is degraded.
3) Phage injects its DNA into the host cell. division.
4) Phage DNA is integrated into host cell Bacterial cell survives and divides.
5) Phage DNA is packaged into phage heads. chromosome
6) Phage DNA is transcribed and translated to make new phage particles.
7) Bacterial cell lyses, releasing phage particles
8) Phage chromosome circularizes
A. Lytic cycle
B. Lysogenic cycle
C. Both the lytic and lysogenic cycles

Answers

Answer:

The correct statements are sorted under respective life cycles below:

Explanation:

A. Lytic cycle:

Bacterial chromosome is degraded.

5) Phage DNA is packaged into phage heads.

6) Phage DNA is transcribed and translated to make new phage particles.

7) Bacterial cell lyses, releasing phage particles

B. Lysogenic cycle

1) Phage DNA is replicated along with the bacterial chromosome during cell division.

4) Phage DNA is integrated into host cell, and Bacterial cell survives and divides

C. Both the lytic and lysogenic cycles:

8) Phage chromosome circularizes

2) Phage attaches to host cell

3) Phage injects its DNA into the host cell.

Which describes oxygen content as Earth evolved over time? Oxygen levels sharply declined about 400 million years ago. Oxygen levels stay above 15 percent starting 200 million years ago Oxygen levels remain below 5 percent starting 1000 million years ago. Oxygen levels raise significantly between 1000 and 700 million years ago.

Answers

Answer:

Oxygen levels stay above 15 percent starting 200 million years ago

Explanation:

Atmospheric oxygen levels are related to the evolution on Earth and changes in geochemical cycles that involve climate variations.

The presence of O 2 and evolution of oxygen gave new opportunities to the life on Earth. Oxygen levels in atmosphere have fluctuated between 15% and 35% of atmospheric volume, since the start of the Cambrian period.

So, form the starting 200 million years ago, oxygen level stay above 15 percent and the correct option is "B".

Answer:

b

Explanation:

ASAP Mitosis and Meiosis have all of the following in common, except: A. Both duplicate their DNA first B. Both result in cell division C. Both have chromosomes line up in the middle of the cell D. Both result in genetically identical daughter cells

Answers

Answer:

D

Explanation:

they both produce daughter haploid cells.

Mitosis and Meiosis have all of the following in common, except both results in genetically identical daughter cells. Thus, the correct option is D.

What is Meiosis?

Meiosis may be defined as the type of cell division that forms four daughter cells that are haploid in nature from a parental cell. It is also known as reductional division.

The common methods of both types of cell division are both duplicate their DNA first, both result in cell division, and both have chromosomes line up in the middle of the cell.

Mitosis is only the type of cell division that results in the formation of two genetically identical daughter cells.

Therefore, the correct option for this question is D.

To learn more about Mitosis and meiosis, refer to the link:

https://brainly.com/question/88103

#SPJ5

In the newly engineered cell created by the researchers at the JCVI, what was derived from a previous cell, partially supporting one aspect of cell theory?

Answers

Answer:

Cells can only derive from pre-existing cells.

Explanation:

The cell theory has three major postulates: 1-all organisms are composed of cells, 2-the cells are the basic unit of all living forms, and 3-the cells derive from pre-existing cells. In 2010, the J. Craig Venter Institute (JCVI) designed in the laboratory a synthetic bacterium that is able to auto replicate himself, and thereby supporting the third statement of the cell theory. This bacterium was named as Mycoplasma mycoides JCVI-syn1.0 and its creation represented a milestone in synthetic biology. M. mycoides is a bacterium that has only 473 genes coded by 531,000 bases pairs (bp), this being one of the smallest genomes of all living forms.

Which of the following could be discovered by studying the gross anatomy of a cadaver?
The function of cells within the body
The types of cells within each organ
The function of the body's organs and systems
The structure of the body's organs and systems

Answers

Answer:

The structure of the body's organs and systems

Explanation:

In medicine, a cadaver is a dead human body dissected in order to study its anatomical structure. It is employed by medical students and other medical practitioners to study the structure of the human body.

Anatomy is a branch of science that has to do with the study of the structure of living organisms. Relating anatomy to cadaver, these dead bodies are dissected in order to view and study the structure of the different compartments of the body e.g organs, systems etc.

Ostriches can evade predators by running away on their powerful legs.
Please select the best answer from the choices provided
T
F

Answers

Answer:

True

Explanation:

When threatened, ostriches run away, but they can cause serious injury and death with kicks from their powerful legs. Contrary to popular belief, ostriches do not bury their heads in sand to avoid danger. This defensive behavior of lying low, so that they may appear from a distance to have their head buried.

Why is oceanic crust subducted under continental crust?
A. Oceanic crust is moving faster than continental crust.
B. Oceanic crust is denser than continental crust.
C. Oceanic crust is less dense than continental crust.
D. Oceanic crust is older than continental crust.

Answers

Answer:

B.) Oceanic crust is denser than continental crust.

Explanation:

Oceanic crust is denser, so it is subducted under the continental crust. The less dense magma then rises up through the continental crust, then it's further increasing the size of the continental crust and then maintaining it's lower density than the oceanic crust, which then causes subduction.

I hope this helped. I am sorry if you get this wrong.

Answer:

B.) Oceanic crust is denser than continental crust.

Explanation:

I just did it and got it right :)

what is an example of facilitated diffusion

Answers

Answer:

Fructose

glucose

some of the Aminoacids

Read the following scenarios and indicate which of the following processes they describe.

1. Sodium ions (Na ) move through sodium channels in a synthetic membrane.
2. Sodium molecules move randomly around a solution of sodium chloride in water, frequently colliding with other sodium ions and chloride ions.
3. Water molecules move into the cytosol of a cell placed in a hypotonic solution.
4. Water molecules move into the cytosol of a cell placed in pure water.
5. The action of sodium-potassium pumps moves sodium ions (Na ) out of a cell and potassium ions (K ) into a cell. The action of sodium-potassium pumps moves sodium ions (Na ) out of a cell and potassium ions (K ) into a cell. The action of sodium-potassium pumps moves sodium ions (Na ) out of a cell and potassium ions (K ) into a cell.
6. Glucose molecules move into cells lining the intestine against their concentration gradient driven by the movement of sodium ions (Na ) into the cells down their concentration gradient.

Answers

1.facilitated diffusion

2.diffusion

3.osmosis

4.osmosis

5.active transport

6.cotransport

PLS PLS PLS HELP Other than distance from the sun, which factor affects the temperature of a planet? (not just earth) Explain your answer in complete sentences.

Answers

Answer:

Another factor besides distance from the sun would be "atmospheric composition".

Explanation:

Other than distance from the sun, atmospheric composition affects the temperature of a planet. Atmospheric composition is the amount of energy that gets to the exterior of a planet. The energy that gets to the exterior of a planet, affects the temperature.

where do scientist obtain primers to be used in pcr and in this technique

Answers

Answer:

Scientist obtain the primers from the DNA polymerases that preform the synthesis which must have an existing strand of nucleotides already in order to attach new DNA nucleotides. The existing strand of new DNA nucleotides is the primers

Explanation:

In order to happen DNA synthesis of a wanted portion of DNA in laboratory,

Scientist obtain the primers from the DNA polymerases that preform the synthesis which must have an existing strand of nucleotides already in order to attach new DNA nucleotides. The existing strand of new DNA nucleotides is the primer. To that existing strand of nucleotides we call primer. In a lab, scientists produce DNA primers through specific sequences that bind to other sequences of a single-thread DNA molecule and these are the primers commonly used to perform PCR.

Why do organisms go through the process of meiosis?

Answers

Answer:

Meiosis is essential for sexual reproduction and therefore occurs in all eukaryotes (including single-celled organisms) that reproduce sexually. ... These resultant haploid cells can fuse with other haploid cells of the opposite sex or mating type during fertilization to create a new diploid cell, or zygote.

Explanation:

What are 4 questions to understand behavior

Answers

Explanation:

1. What u like doing

2. What u dislike

3. What easily gets u angry

4. What makes u happy

That's how I understand it

Which of the following explains the process of evolution?

-a process of change in a population through genetic variation over time

-the genetic variation within a species

-a change in one species that results from a change in a different species with which it int

Answers

Answer:

1st option

Explanation:

they adapt throught genetic variations

processes involved when an eye views an object

Answers

Answer:

cornea

Explanation:

When light rays reflect off an object and enter the eyes through the cornea (the transparent outer covering of the eye), you can then see that object. The cornea bends, or refracts, the rays that pass through the round hole of the pupil.

What material is compressed underground to form fossil fuels?
O A. Oxygen and carbon dioxide
B. Dead plants and animals
C. Greenhouse gases
O D. Water and ice

Answers

Answer:

b

Explanation:

A fossil fuel is a fuel formed by natural processes, such as anaerobic decomposition of buried dead organisms, containing organic molecules originating in ancient photosynthesis that release energy in combustion.

Answer:

b,2

Explanation:

b,2

Recall what you know about crossing over, independent assortment, and random joining of sex cells during sexual reproduction. Now, go back to the claims in Step 2a. Do you support these claims? If so, do you support the totality of the claims or just parts of the claims? Based on your prior knowledge, make a claim about the factors that cause inherited genetic variations within populations. Also make a claim about the effects of mutations. Write your claim in your notebook. ASAP!!!!

Answers

Answer:

Crossing over is a process in which exchange of segments occur.

Explanation:

Crossing over is a process in which two non-sister chromatids of homologous chromosomes exchange the segments of genetic material with each other during meiosis. Due to this process, variation occurs in an organism.

Independent assortment is a process in which different alleles are sorted to different gametes which occurs independently and does not effect one another. This process occurs in metaphase of meiosis l.

Joining of sex cells is a process in which sex cells of male and female join together formed a zygote which turn into a new organism. These sex cells are formed during meiosis which are haploid in nature.

Mutation and crossing over are the factors that cause inherited genetic variations within populations.

Sudden change occurs in the genes of an organism due to the exposure of the cell to radiation or chemicals.

While you are running and approaching your first mile, oxidation of free fatty acids is taking place at the cellular level, allowing you to continue running.
a) anaerobic metabolism
b) aerobic metabolism
c) lactic acid metabolism

Answers

answer

B) aerobic metabolism

(Aerobic metabolism is the way your body creates energy through the combustion of carbohydrates, amino acids, and fats in the presence of oxygen. Combustion means burning, which is why this is called burning sugars, fats, and proteins for energy.)

Some organisms are made of single cells and live in the hot acidic environment of deep ocean vents.
Some organisms are single cells and live one the surface of your skin.
And there are small multicellular organisms that make fuzzy circular growth on old bread.
And of course, roses with pretty flowers are organisms.
And whales.
That’s a lot of diversity. So let’s say I think those creatures are just so different that they just couldn’t ALL be related to each other. Using specific traits, convince me that all of these organisms can be traced back to a common ancestor. (At least 6 well-chosen traits required for full credit.)
Write your answer in the essay space.

Answers

Answer:

All organisms are composed of cells that share a structural organization and play roles in similar biological processes.

Explanation:

All living organisms can be grouped in terms of cellular organization, functioning, and structure. These features enable us to define them as “subjects” of life. Organisms share basic biological mechanisms such as, among others, growth, homeostasis, development, energy processing, reproduction, etc. Moreover, life is also defined by the presence of essential biomolecules such as DNA, RNA, proteins and lipids. Finally, the cell is considered to be the basic unit of every life form, and organisms may be formed by one (unicellular) or more cells (multicellular). The fundamental feature of the cell is the presence of a membrane that separates it from the external environment, thereby defining its internal environment.

Other Questions
PLEASE HELP ILL GIVE BRAINLIEST!! What is the solution to this system of equations? In two to three paragraphs, explain how Vietnams political boundaries, affiliations, and alliances changed from the end of World War II to 1975, when the country finally achieved independence. Based on your research, include the causes and effects of foreign aggression on Vietnam during this period. 1| def saveUserProfile(firstName, lastName, age, height, country):2| filename = lastName + firstName + ".txt"3| outputFile = open(filename, "w")4| print(lastName, file = outputFile)5| print(firstName, file = outputFile)6| print(country, file = outputFile)7| print(height, file = outputFile)8| print(age, file = outputFile)9| outputFile.close()Above is a function that takes five pieces of information about a user and saves that data to a file. We'll assume firstName, lastName, and country are strings, age is an integer, and height (expressed in meters) is a float.Assume we call the function above with this line of code:saveUserProfile("David", "Joyner", 30, 1.8, "USA")After the function runs, what is name of the file that is created?a. What is written on line 1 of that file? If there is no line 1 or if line 1 is blank, enter Nothing. b. What is written on line 2 of that file? If there is no line 2 or if line 2 is blank, enter Nothing.c. What is written on line 3 of that file? If there is no line 3 or if line 3 is blank, enter Nothing. d. What is written on line 4 of that file? If there is no line 4 or if line 4 is blank, enter Nothing. e. What is written on line 5 of that file? If there is no line 5 or if line 5 is blank, enter Nothing. box with a a square base and open top must have a volume of 62,500 cm3. Find the dimensions of the box that minimize the amount of material used. sides of base A stone is dropped from the upper observation deck of a tower, 600 m above the ground. (Assume g = 9.8 m/s2.) (a) Find the distance (in meters) of the stone above ground level at time t. (b) How long does it take the stone to reach the ground? (Round your answer to two decimal places.) (c) With what velocity does it strike the ground? (Round your answer to one decimal place.) Remember that velocity requires direction. (d) If the stone is thrown downward with a speed of 7 m/s, how long does it take to reach the ground? (Round your answer to two decimal places.) Write an equation perpendicular to 5x+6y=18 that passes through the point (10,7) 1. What is an inequality? Give one example of an inequality? How would you graph this? 2. What is a compound inequality? Give an example of "and" and an "or" inequality. 3. 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You must answer as a number i.e if you think the answer is 12, you must enter 12, not twelve. Babies that are at a low birth weight are more likely to have health problems, while women will have difficulty delivering babies with high birth weight. Together this leads to ________ for babies of average birth weight.a. Stabilizing selectionb. Disruptive selection *HELP* Select the correct answer. What is the value of this expression when t = -12? -3|t 8| + 1.5 A. 61.5 B. 13.5 C. -10.5 D. -58.5 In some parts of Africa, the frequency of heterozygosity for the sickle cell anemia allele is unusually high, presumably because this reduces the frequency of malaria. Such a relationship is related to which of the following?a) Mendel's law of independent assortmentb) Mendel's law of segregationc) Darwin's explanation of natural selectiond) Darwin's observations of competitione) The malarial parasite changing the allele Hellppp Ethanol, an organic compound, has the following structural formula.H---01H What is the chemical formula of Ethanol Ch6oC2H5OC2H5OC2H6O6 The broad-ranging federal legislation that transformed the federal government's role in the American economy during the first two years of Franklin D. Roosevelt's presidency brought the nation out of economic depression, and resulted in nearly full employment.a) trueb) false What is the solution to the system of equations below? y = negative one-third x + 6 and x = 6 What does Electromagnetic induction mean? Transformers are of two types: Step up and Step down. What is step up transformer?What is step down transformer?What is the difference between them? Please I really need help.Don't answer the question for points if you don't know what it means! SUSSEX Pledge a. increased the size of the army and the National Guard b. suggested an alliance between Mexico and Germany c. took over the railroads d. set up a draft e. planned cooperation among all countries f. improved relations between Germany and the United States for a time g. prohibited interference with the war effort h. helped to finance the war A cylinder fits inside a square prism as shown. For every cross section, the ratio of the area of the circle to the area of the square is or . Since the area of the circle is the area of the square, the volume of the cylinder equals the volume of the prism or (2r)(h) or rh. the volume of the prism or (4r2)(h) or 2rh. the volume of the prism or (2r)(h) or r2h. the volume of the prism or (4r2)(h) or r2h.