Cholesterol has a much higher profile than the other lipids because of its association with heart disease. Despite its lethal reputation with the public, cholesterol is vital to the body: it maintains proper fluidity of animal cell membranes and is the precursor of steroid hormones such as progesterone, testosterone, estradiol, and cortisol. Cholesterol is synthesized in the liver and, to a lesser extent, in other tissues. The rate of its synthesis is highly responsive to the cellular level of cholesterol. Cholesterol synthesis can be effectively blocked by a class of compounds called statins. The market of the statins is estimated at $20 billions.
Explain the mechanism of action of statins.

Answers

Answer 1

Answer and Explanation:

The mechanism of action of statins begins with the inhibition of a protein called HMG-CoA reductase, allowing its substrate to accumulate in the body and promote cholesterol reduction. At that moment, a transporter called OATP (Organic Anion Transporting Polypeptides) takes statins to the epatic tissue where they will be transformed and metabolized until they are eliminated through bile. This elimination is influenced by the P-glycoprotein, which is the main cause of the efflix presented by the bili. This process can get help from other molecules like some protease inhibitors, digoxin and cyclosporine.


Related Questions

What is Respiration?

Answers

Biology Definition: Respiration is a chemical reaction that happens in all living cells. (Both plant cells and animal cells). Respiration is the way that energy is released from glucose so that all the other chemical processes needed for life can happen.

Normal definition: The action of breathing, also called ventilation.

___________________________________________________________

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Why do we cut the celery stem under water

Answers

Answer:

Hey! Neko here!

Explanation:

That new empty space inside the leaves creates a low pressure, and like a drinking straw, this low pressure allows water below the leaf to travel up the stem. You’ll see the little tubes the water travels up when you cut the celery stem, and you can see the colour up in the leaves.

hope this helps ig! <3

We cut the celery stem under water to see the color change in the stem due to movement of water through the process of transpiration in the cell.

What is Celery stem?

Celery stalks or stems are the petioles of the compound leaves. They are not the stems, in spite of the widespread misrepresentation in elementary school lesson plans only. They may also look like the stems to some people because they are thick and fleshy due to accumulation and have prominent veins which are running lengthwise through them.

When we cut the little tubes or celery stem under water travels up when and we can see the color up in the leaves. This process is called as transpiration. The new empty space which is present inside the leaves creates a low pressure, and just like a drinking straw, this low pressure allows the water below the leaf to travel up the stem.

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Compare and contrast the random sampling and mark and recapture methods of
estimating population sizes. Describe a situation in which each method would
work best and why. Justify your answer.

Answers

Explanation:

jennjjj+ii8iiiiiiiuiiiiiiiu

Random sampling and mark and recapture methods are both commonly used to estimate population sizes, but they have different strengths and weaknesses.

What is random sampling?

Random sampling involves selecting a random sample of individuals from a population and using that sample to make inferences about the population as a whole. This method is typically used when the population is large and diverse, and it is difficult to observe or count all individuals. Random sampling is also useful when the population is not easily marked or tagged, as it does not rely on the use of markers.

On the other hand, mark and recapture methods involve marking a subset of individuals in a population, then releasing them back into the population and later re-capturing them. The number of marked individuals that are recaptured is used to estimate the population size. This method is typically used when the population is small, and it is relatively easy to observe or count all individuals. Mark and recapture methods are also useful when the population is easily marked or tagged, such as with fish or birds.

A situation in which random sampling would work best is a study of the population of deer in a large forest. The forest is too vast to observe or count all individuals, so a random sample of deer would be selected and observed to estimate the population size.

On the other hand, a situation in which mark and recapture methods would work best is a study of the population of fish in a small lake.

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What might be the result if you shuffle the order of bases in an organism's DNA
molecules?

Answers

Answer:

It would have disastrous consequences on the viability of the individual

Explanation:

The genome can be defined as the genetic material of an organism, which is composed of DNA molecules named chromosomes whose building blocks are four different nucleotides: Adenine, Thymine, Cysotcine and Guanine. The order of these nucleotides specifies the information contained in the chromosomes and, ultimately, in the genome. The genes, which are recognized to be the basic units of inheritance, are genetic sequences composed of ordered nucleotides along the chromosomes. During transcription, a gene encodes different RNA codons (for example, start and stop codons) which are specified by the order of the nucleotide sequence. Finally, the order of the RNA codons will be critical to specify the polypeptide chain during the translation from RNA to protein.

Which of these is describing a Eutrophic Lake?


A Mucky Water
B Cold Water
C Low Biodiversity
D Rocky Bottomed
Plz answer

Answers

Answer:

Mucky Water

Explanation:

I'm in high school Aquatics and I had this question popped up

While looking through a powerful microscope, you notice a type of one-celled organism you have not
seen before. Which of the following would help you classify the organism as a prokaryote or a
eukaryote?
a. Presence of a cell membrane
b. Presence of ribosomes
C. Presence of cilia or flagella
d. Presence of membrane-bound organelles

Answers

Answer:

d. Presence of membrane-bound organelles

Explanation:

Living organisms has been classified into prokaryotic or eukaryotic depending on the content of their cell. The basis of classification into prokaryote or eukaryote is the possession or not of a membrane-bound nucleus or organelle.

According to this question where a one-celled organism was seen in a miscrosope, PRESENCE OF MEMBRANE-MEMBRANE-BOUND ORGANELLES is the characteristics that will help in the classification of the organism as a PROKARYOTE OR EUKARYOTE.

Presence of membrane-bound organelles would help classify the organism

as a prokaryote or eukaryote.

Prokaryotes are defined as organism which don't have a true nucleus as a

result of the absence of the nuclear membrane. Eukaryotes on the other

hand have a true nucleus as a result of the presence of the nuclear

membrane.

When viewing a one-celled organism with a microscope, we are able to

classify the organism based on the presence or absence of a membrane-

bound organelle.

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predict whether a pot of water heated from the top would boil more quickly than a plt of water heated from the bottom. Explain your answer.​

Answers

The bottom because the heat would rise to the top causing more bubbles convection currents to form. The top heated from the top would heat more slowly than a pot heated from the bottom.

Water will boil faster when it is heated from the bottom rather than when it is heated from the top.

The boiling of water occurs due to convection currents. Heavier particles moves from upwards and travels downwards and then they are replaced by lighter particles traveling upwards. This is called convection currents.

As such, water will boil faster when it is heated from the bottom rather than when it is heated from the top.

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Which of the following is true? A b c d

Answers

Answer:

C

Explanation:

high fat diet is always bad for the body! it makes you gain weight, it makes you get heart problems, cancer, PCO(in ladies), muscle, bone, neck and back aches and most importantly, it makes your cells insulin-resistant which could cause type 2 diabetes.

if it is unclear or you need more explanation, ask freely. also if the answer was correct, please give me brainliest. I need them!

Tina creates the layered column of liquids shown below to demonstrate certain characteristics of the layers of the Earth Oil (density 0.s5 omL) Water (dernsity 1.00 pim -Corn syrup (densily 1.02 gml Density Column Which of the following is the biggest limitation of how this model can represent Earth? O Convection is not possible in this model OWaves, such as seismic waves from an earthquake, are not able to travel through this model O Density is not an important characteristic of Earth's layers O Relative thickness of the layers is not accurate​

Answers

Answer:i think it’s B. Waves such as

Explanation:

Which states of matter have no definite shape or volume

Answers

The state of matter is gases
That would be gas states

What is the purpose of checkpoint proteins? *

Answers

Answer:

The key role of checkpoint proteins is to detect DNA damage and send a signal to delay cell cycle advance until the damaged chromosomes are repaired

Explanation:

The sodium-potassium pump is a membrane protein that pumps sodium out of the cell and brings potassium in. It does this against the concentration gradients; in other words, it pushes both molecules from areas of low concentration to areas of already high concentration. What type of transport is this?
a.passive transport, which requires energy
b.passive transport, which does not require energy
c.active transport, which requires energy
d.active transport, which does not require energy

Answers

B ;) _____________________________

What is the difference between a food chain and a food web?​

Answers

Answer:

Food chain: only shows the common sequence from producer to one tertiary consumer. Basically it only shows one sequence in which energy is distributed among the animals and plant life.

food web: provides a broader spectrum on the distribution of energy among the ecosystem of that terrain.

Select the four statements that are true. Select the four statements that are true.
Based on the equation for Hardy-Weinberg equilibrium, the expected number of wolves with the FBFB genotype is 40.
Based on the equation for Hardy-Weinberg equilibrium, the expected number of wolves with the FBFB genotype is 12.
Based on the equation for Hardy-Weinberg equilibrium, the expected number of wolves with the FBFW genotype is 40.
Based on the equation for Hardy-Weinberg equilibrium, the expected number of wolves with the FBFW genotype is 96.
The population is not at Hardy-Weinberg equilibrium. The population may be evolving because the actual number of individuals with each genotype differs from the expected number of individuals with each genotype.

Answers

Answer: Based on the equation for Hardy-Weinberg equilibrium, the expected number of wolves with the FBFW genotype is 96.

Based on the equation for Hardy-Weinberg equilibrium, the expected number of wolves with the FBFB genotype is 12.

The population may be evolving because the actual number of individuals with each genotype differs from the expected number of individuals with each genotype.

The population is not at Hardy-Weinberg equilibrium.

Explanation:

The FB allele should accounts for 120 of the alleles (40 × 2 = 80 in FBFB wolves, + 40 × 1 = 40 in FBFW wolves).

the FB allele would make up 20% (120/600) of the total alleles in the population, so the value of p would be 0.2. The allele frequencies of the population must add up to one for it to be valid (what this means is p+q=1); therefore, since the value of p is 0.2, and the value of q is 0.8.

According to the Hardy-Weinberg equation, the expected frequencies of the genotypes would add up to 1.

= p2+2pq+q2

= 1

or

= 0.22+2(0.2)(0.8)+0.82

= 1

or

= 0.04+0.32+0.64

= 1

Answer:

Is this population in Hardy-Weinberg equilibrium?

✔ No

Which allele is increasing in the population?

✔ Allele C

Explanation:

Edge 22

Transposons are movable elements of DNA that insert into new positions within the genome. A transposon may disrupt normal gene function, confer an evolutionary advantage, or have no effect on the organism.
Select all scenarios in which a transposon has positively contributed to the evolution of the host's genome.
a. insertion of a transposon encoding a heat shock protein into the genome of a plant
b. insertion of a transposon into the gene encoding for dystrophin, a protein involved in skeletal movement and cardiac function
c. aquisition of a transposon carrying an adhesin gene into the Lactobacillus casei genome
d. acquisition of a transposon that disrupts
e. an enhancer element of a colorectal cancer tumor‑suppressor gene acquisition of a transposon carrying a tetracycline resistance gene in a bacterium

Answers

Answer: Transposons are genomic sequences that can cause or reverse mutations by changing its positions.

Explanation:

a., and c. are the correct options.

The heat shock protein encoded by the transposon will increase the thermotolerance of the transgenic plant. It will also improve it's stress tolerance.

The adhesin genes will enable the bacteria to stick on the walls of the intestinal tract of humans and this will help human body in digestion process.

explain where you observe reflection refraction and absorption of light in your every day life

Answers

Answer:

Reflection: you look in the mirror.

Refraction: You put a straw in a glass of water, and it looks like it broke.

Absorption: If you have a black sweater and you wear it out in the cold, the black sweater is going to hold in heat better than a lighter sweater because the black sweater absorbs light .

Roots____.
soak up water from the soil
hold the plant in the ground
store food and water
all of the above

Answers

All of the above!

Im 100% sure this is correct :)

Is Food a better source of nutrients than dietary supplements.

Answers

Answer:

Supplements can plug dietary gaps, but nutrients from food are most important. The fresh food you eat is loaded with nutrients necessary for good health, such as magnesium, calcium, and vitamins A and C. But many older adults aren't getting enough nutrients from their diets.

Explanation:

food is a better source of nutrients

"list eight details that must be documented when a vaccine is given?"

Answers

“Date vaccine was administered, write vaccine's manufacturer, type of vaccine and the dose, exact site injection was given, any reported/observed side effects, publication date of the VIS form given to the parent, parent education about possible side effects, and name and title of person who administered the vaccine.” Brainliest answer? :) Hope this helps !!

In 1947, pilot Chuck Yeager became the first person in an airplane to fly faster than the speed of sound. He flew his plane about 12,000 meters above sea level. At that altitude, the speed of sound travels at 290 meters/second. At sea level, the speed of sound is about 340 meters/second. What conclusion can you make from this information?
A The speed of sound does not depend on altitude.
B The speed of sound depends on the type of plane flown.
C As the altitude increases, the speed of sound increases.
D As the altitude increases, the speed of sound decreases.

Answers

I think answer should be d. Please give me brainlest I hope this helps let me know if it’s correct or not okay thanks

What does primary succession begin with

Microbes
Plants
Bare rock
Soil

Answers

It begins with Bare Rock

Answer:

primary succession begins with bare rock

Explanation:

hope this helps :)

Which of the following statements regarding the human
population are TRUE? Select TWO.
SELECT ALL THAT APPLY
The world's population of humans is
increasing.
In every country, the human population is
increasing.
In some countries, the human population is
decreasing or staying the same.
The world's population of humans is
staying constant

Answers

Answer: Which of the following statements regarding the human

population are TRUE? Select TWO.

The world's population of humans is

increasing.

In every country, the human population is

increasing

In some countries, the human population is

decreasing or staying the same.

The world's population of humans is

staying constant.

Which of the following statements regarding the human

population are TRUE? Select TWO.

The world's population of humans is

increasing.

In every country, the human population is

increasing

In some countries, the human population is

decreasing or staying the same.

The world's population of humans is

staying constant.

Which of the following statements regarding the human

population are TRUE? Select TWO.

The world's population of humans is

increasing.

In every country, the human population is

increasing

In some countries, the human population is

decreasing or staying the same.

The world's population of humans is

staying constant.

Which of the following statements regarding the human

population are TRUE? Select TWO.

The world's population of humans is

increasing.

In every country, the human population is

increasing

In some countries, the human population is

decreasing or staying the same.

The world's population of humans is

staying constant.

Which of the following statements regarding the human

population are TRUE? Select TWO.

The world's population of humans is

increasing.

In every country, the human population is

increasing

In some countries, the human population is

decreasing or staying the same.

The world's population of humans is

staying constant.

Explanation:

Which of the following statements regarding the human

population are TRUE? Select TWO.

The world's population of humans is

increasing.

In every country, the human population is

increasing

In some countries, the human population is

decreasing or staying the same.

The world's population of humans is

staying constant.

The study of population is called demography.

The correct answer is A and C.

A group of the same species living together and interacting with other species is called a population.

The changes in the population are as follows:-

IncreasingDecreasingNeutral

The population can never be constant. The world's population is increasing every day. The birth rate is higher than the death rate.

But in countries, the population is decreasing because there the birth rate is lesser than the death rate due to which the population is decreasing.

Hence, the correct answer is A and C.

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Which table correctly identifies the four most abundant elements in biomolecules

Answers

Answer:

are hydrogen, oxygen, nitrogen, and carbon,

Explanation:

which together make up over 99% of the mass of most cells. They are the lightest elements capable of forming one, two, three, and four bonds, respectively

The four most abundant elements in biomolecules are hydrogen, oxygen, nitrogen, and carbon,

What are different types of biomolecules ?

The basic building blocks of the living organism are called as biomolecules which are Carbohydrates, Proteins, Fats, Nucleic Acids which make the components of a living cell.

Carbohydrates are polyhydroxy aldehydes or ketones collectively called as saccharides, it can be monosaccharide, oligosaccharide and polysaccharides based on the number of sugars in it.

Proteins are polymers of amino acids where number of amino acids are joined by peptide bond to form polypeptide chain which further converted into protein and it can be classified as primary, secondary, tertiary and quaternary protein.

Nucleic acids are up nitrogenous base, sugar and phosphate; It can be up two types namely, deoxyribonucleic acid (DNA) and ribonucleic acid (RNA).

The nucleic acid carries the genetic information which is transferred from parent to next generation and proteins which express the genetic character by processes of transcription and translation.

Lipids are organic insoluble fat like substance, soluble in organic solvents like oil,  they include sterols, fat-soluble vitamins, mono-, di- or triglycerides, phospholipids, etc.

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Which list of organelles would you associate with an animal cell?
O A cytoplasm, nucleus, cell membrane, large vacuoles
B. cytoplasm, nucleus, endoplasmic reticulum, cell wall
O c. cytoplasm, nucleus, Golgi bodies, cell wall
O D. cytoplasm, nucleus, lysosome, ribosomes
O E. cytoplasm, nucleus, mitochondria, chloroplasts

Answers

D. cytoplasm, nucleus, lysosome, and ribosomes.

animal cells don't have a cell wall, they only have a cell membrane. They also don't have a large vacuole.

so sorry if i'm wrong! hope this helps!

what is the word for this definition?

when an elements has more then one type each with the same number of protons but a different number of neutrons.

a. radioactive decay
b. half life
c. isotopes
d. daughter atoms​

Answers

When an atom varies in its number of neutrons but not its protons it is called an isotope
atom varies so the answer is d i suppose

Is there cytoplasm in cork cells?

Answers

no there is not so there ya go

cytoplasm is mainly found in cells of living things

Which image represents the step in mitosis when chromosomes condense and spindle fibers form?

Answers

Answer:

The process you described is called prophase

Explanation:

Since you dId not provide the pictures, this is what it's supposed to look like.

Answer:

A

Explanation:

The three domains are___.

Answers

But he is answering what are the three trinomial‘s

For question 6 only :)

Answers

Answer:

B

Explanation:

Producers are organisms that create food from inorganic matter. The best examples of producers are plants, lichens and algae, which convert water, sunlight and carbon dioxide into carbohydrates. Consumers are organisms that cannot create their food. I think hehe


Which of these statements about African slaves in America is true?
A. They could meet in groups.
B. They could get an education.
о
C. They had no rights under the law.
D. All of the above

Answers

Answer: C.

Explanation:

Slaves did not have any rights

The statements about African slaves in America are true: they had no rights under the law, which is option C, as the African slaves in America were denied basic human rights and were treated as property rather than as human beings.

What are African slaves?

The enslavement of Africans in America is a dark and painful chapter in the history of the United States. Beginning in the early 17th century, millions of Africans were forcibly brought to America and sold into slavery, where they were subjected to a lifetime of bondage, exploitation, and abuse. Under the system of slavery that existed in America, slaves had no legal rights and were not recognized as human beings under the law.

Hence, the statements about African slaves in America are true because they had no rights under the law, which is option C.

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Anwser these questions for 50 points Use a proportion to convert the measurement.10 yards =_______meters Apply to a Successful fitness program PLEASE HELP!!! ILL GIVE BRANLIEST *EXTRA POINTS* dont skip :(( The bottom of Paul's fish tank is a square shape that has an area of 64 square inches.Paul wants to buy a decorative square plate to put in the bottom of the tank. Whatshould be the length of the sides of the plate that Paul buys? what was the main reason the oigrims gave for creating the mayflower compact If Steve paid back $7,945 on a $7000 simple interest loan after 3years. What was the interest rate? The word "spunk can also mean courage, bravery, or determination. Which character do you think has the most spunk? Why True or False: every place on earth has a location on theplanet's surface A square patio has an area of 180 square feet. How long is each side of the patio to the nearest tenth?Each side of the patio is approximatelyfeet long I have a picture I really need help with math please someone What is a political party, how many are there,and how do they communicate their beliefs? Which details in the exposition of the story indicate why mr.sasaki hires teruo page 462 ?????????????????????? Help???plzz What do the sensors in our bodies monitor ? How does and adolescent's thinking differ from that of a child? According to historian Pauline Maier in Liberty, the great paradox that needs to be explained is:A.) That despite the warnings from Parliament, colonists did not understand that their actions would lead to a revolution and this was owing to the difficulty in communication.B.) How in a mere thirteen years, colonists went from being proudly and optimistically British to declaring their independence and that they did was unexpected to all who lived during that time. C.) That abolitionists in the northern colonies would united with slave holders in the southern colonies to fight for independence and the natural rights of man.D.) That the elites were in charge of seeking independence and forced the working classes to join in the effort against their will and interests ........... is the fields of ice that have built up over millions of years. Which ordered pair best represents the location of the y-intercept?A)(2.5, 0)B)(0, 2.5)C)(-5, 0)D)(0, -5) 3. A stuntman jumps off a building (into a safety mat). If he falls for 5 seconds, whatwill his velocity be right before he hits the mat? (please include direction)Givens (include all variables and units. Ex. vi=5m/s, d=60miles)