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which of the following does not form part of the systemic circulation? A. Right atrium B. Aotra C. left lung D. Vena Cava
Explanation:
Systemic Circulation
Related terms:
ChitosanDrug DeliveryNanoparticlesNanomaterialsProteinAortic ValveBiodistributionHydrophilicPolymeric Micelle
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Nanoscale Drug-Delivery Systems
Anthony Singer, ... Shyam S. Mohapatra, in Nanocarriers for Drug Delivery, 2019
5.2 Challenges of Systemic Circulation and Cellular Internalization
In systemic circulation there is a danger of fouling, which is essentially the loss of function of NPs due to degradation, alteration, or mild to severe denaturation due to natural internal interactions during administration [60]. This must be accounted for in the design of the nanoformulation by conjugation of antifouling (stabilizing) agents that will maximize the stability and protection of its conjugate. In addition, any specific barriers encountered during administration must be taken into consideration by employing a mechanism to overcome the barrier. Stabilizing agents also aid in extending the half-life, maximizing delivery to the target site, preventing nonspecific premature drug release or nonspecific cellular uptake, and overall eliminating cytotoxic effects. Targeting also enhances specific delivery. Another challenge of free NPs in the systemic circulation is the prevention of opsonization, which signals for degradation and clearance from the bloodstream. This can be prevented by conjugating specific polymers, such as PEG. Size also plays a role in whether the NP is detected. Last, any NP that enters the human body and is immersed in body fluids can become coated by natural body proteins forming a protein corona [60]. In response, the NP's in vivo physicochemical interaction can be inhibited or altered to the point that its therapeutic function is lost. For example, a natural protein can successfully compete for a targeting moiety and prevent the intended ligand–receptor interaction. However, the protein corona can be controlled by functionalization to inhibit its formation or bond specific types of proteins that could aid in delivery or protection [60].
If there are no extracellular release stimuli when a target cell is reached, the intracellular delivery for an NP highly depends on its ability to survive cell entry, or internalization. This process typically relies on a phagocytic path of entry, which exposes the NP to acidic environments and also requires endosomal vacuole escape [53]. Other paths may include entry through pores in the cell membrane or facilitation by transmembrane proteins. If release is not intended to be cytoplasmic, then conjugates to aid in intracellular trafficking must be employed to cause organelle-specific drug delivery [54]. Mitochondria and the nucleus of a cell are often targeted organelles, but both have membranous barriers that must be overcome.
Most importantly, nanotherapeutics must be safe. Primarily, the body's cytotoxic response is evaluated, but on top of what has been mentioned in the last paragraphs about stable targeting, the components of the nanotherapeutic must be biodegradable. This means that any unused component, such as the nanocarrier and its conjugates, can be safely broken down and excreted from the body without induction of a cytotoxic effect. In addition, the utilization of biocompatible components (those that are either found naturally in the body or can be naturally metabolized or defended against) severely reduces cytotoxicity [14].
Answer:
It's A(right atrium)
Explanation:
In the systemic circulation, blood travels out of the left ventricle, to the aorta, to every organ and tissue in the body, and then back to the right atrium.
plz help me I need help
Answer:
Night blindness.Hope it is helpfullyProfessor Flummox gives her new test of aptitudes for studying psychology to her psychology students at the start of the year. At the end of the year, she finds that those who did well on the test averaged only a "C" in the course. The test lacks _____.
Based on the information given, the test lacks double blind procedures.
A double-blind procedure is a form of procedure whereby the experimenters or the participants are not aware of who is going to get a particular treatment.In this case, since a test has been done earlier, this will bring about a scenario whereby the professor already knows the excellent students. The double blind procedure is used in order to prevent bias.
In conclusion, the correct option is double blind procedure.
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discuss four contributory factors that may lead to an increase of learners abusing substance
vitural regristance data has poor data coverage . justify.
Answer:
i need poinyd
Explanation:
The three types of muscle are tendons, ligaments, and skeletal.
A. True
B. False
"Human health is the combination of physical, mental & social health". Explain this statement.
Answer:Social health is more than just the prevention of mental illness and social problems. Being socially healthy means increased degree of happiness including sense of belonging and concern for others.
Explanation:
Why should you remove jewelry before you work with food?
Answer:
jewelry can act as a reservoir for germs
Explanation:
The fact is, everyone carries disease-causing microorganisms on and in their bodies — and jewelry can act as a reservoir for germs. That's why if you're a food worker, you should refrain from wearing from wearing anything fancier than a plain ring on your arms and hands when you work.
What does FATTOM stand for
Answer:
FATTOM is an acronym used to describe the conditions necessary for bacterial growth: Food, acidity, time, temperature, oxygen, and moisture. Foods provide a perfect environment for bacterial growth, due to their provision of nutrients, energy, and other components needed by the bacteria.
Explanation:
ALCOHOLS RANK AS AN ABUSED DRUG
The term enteric means pertaining to or of the
Answer: small intestine
Explanation:
Which best describes the strategy of "being flexible" as a way to manage negative emotions related to stress?
Stress is most common in today's generation. People have high expectations not only from others but also from themselves.
If a person is not able to perform the way he expects then there can be negative emotions surrounding him which will cause stress.
An excess stress often leads to depression so it is better to deal with stress just when it starts. The best strategy to deal with stress is to stay calm and being flexible in any situation.
If circumstances are not in the favor of a person, then it is better for him to stay calm and analyze the situation before any reaction.
He should accept the bad situation and then do what he likes examples, listening to songs, reading books or go on a walk.
He should avoid making decisions instantly as any decision made in stress or anger is never worthy.
Learn more at https://brainly.com/question/24400585
Answer:
Learning to move past disappointments or frustrations and work with the situation at hand
Explanation:
A student who constantly gets up out of his seat during class, frequently cuts ahead in the lunch line, and
often has difficulty finding his school supplies is most likely showing signs of which mental disorder?
A anxiety
b.ADHD
C claustrophobia
d. depression
A disorder in which respiratory passageways become inflamed is called ______
A tendonitits
B. asthma
C. anemia
D. ulcer
Answer:
B Asthma
Explanation:
Inflammation and Constriction of the Airways Are Hallmarks of Asthma. Asthma is a chronic disorder involving soreness and swelling of the interior airway walls. It can be triggered by the inhalation of particles from the air. Physical activity or respiratory infections may also contribute.
length of a pencil is 4 cm . what does it mean?
Answer:
the distance from the begining of the pencil till its end it's 4 cm
l = 4 cm
........
What should a person do to treat a first-degree burn?
Immerse burned area in cool water
Apply butter to the surface of the burn
Wrap the burned area tightly with sterile gauze
Place the burned area under hot, running water
Answer:
Immerse burned area in cool water.
But it doesn't mean you should apply very cold water/ ice cold water on the burn. Extreme cold applied to a burn can further damage the tissue.
Answer:
immerse burn area in cool water
Explanation:
1.Don’t use butter on a burn. There’s little to no evidence supporting the effectiveness of butter as a burn remedy. On top of that, it may actually make your burn worse. Butter retains heat and also may be harboring harmful bacteria that can infect the burned skin.
2.Ice and very cold water can actually irritate your burn area more. Ice may even cause a cold burn if used improperly
what is population management
Answer:
Population management, as defined by the Disease Management Association of America, is “a system of coordinated healthcare interventions and communications for populations with conditions in which patient self-care efforts are significant
What is the difference between a virus;bacteria and a parasite?
Answer:
Explanation:
Bacteria and viruses can live outside of the human body (such as on a countertop) sometimes for many hours or days. But parasites need a living host to survive. Bacteria and parasites can often be killed with antibiotics. But these medicines can't kill viruses.
potatoes will retain more nutrients as compared to boiled potatoes. Whole fruits are more nutritious than
.
Answer:
Whole fruits are more nutritious than ( Juices, vegetables, salads ).
Explanation:
6. A client comes to the pharmacy to get a prescription for dextromethorphan filled. The client was most likely diagnosed
with
A. asthma
B. pneumonia.
C. COPD
D. a common cold.
having strong Gig 3 3) What is population education? is
"Population education" is defined in this paper as "the planned and in- tentional educational activities in the school curriculum for the study of human population dynamics, their effects and how they are affected by other economic, social and political factors of human societies."'
Hope this helps!
Write an interview with a doctor/ dietician focusing on a perfect diet for growing children.
Answer:Interviewer: Hello Ma'am, Thank you for taking your time to meet us.
Doctor: No problem. Good Morning.
I : In today's world more and more children are falling prey to disorders that happen during older years. Could improper diet be a reason?
D: Of course. there is so much junk in a child's meals, it is not surprising.
I: What do you thinks should constitute an ideal diet?
D: Less of fried items, of course. Enough of vitamins, carbohydrates, proteins and fats are a must as well. A lot of children drink just a glass of milk for their breakfast and I can't tell you how unhealthy that is. They should be given a proper full breakfast and milk can be given during the evenings after school. Alongwith a proper diet, it is also necessary for them to have physical activities like sports.
I: Yes..
D: Completely avoiding junk food in itself can being about a lot of change.
I: I see.. Thank you, ma'am. Have a nice day.
Explanation:
plz help me I need help
Answer:
Rhinovirus
Explanation:
they cause common cold
Karen is 17 years old and has a BMI that indicates appropriate weight. She loves to eat all kinds of food.
plz help me I need help
Answer:
Carrot
Explanation:
because it's not meat
Answer:
Carrot
Explanation:
Other options are non-veg and rich in proteins.
A mask must cover the nose:
a. To prevent water from entering.
b. To ensure the best possible fit.
c. So that you can keep the pressure inside the mask equal to the pressure outside.
d. Both the first and second answers are correct.
Answer:
d
Explanation:
Your nose is used to filtering out a lot of things and seeing a lot of things. It’s the first line of defense” and catches things like viruses in hair and mucus. You might feel fine if the for example: coronavirus is only in your nose, but breathing or sneezing can send coronavirus particles into the air.
Answer:
d
Explanation:
how does our body respire?
Answer:
Our lungs which are a part of our respiratory system allow us to breathe. The lung brings oxygen into our bodies called inspiration, or inhalation and send CO2 out known as expiration, or exhalation. Thus said this exchange of O and CO2 is known as respiration.
Explanation:
Hope this answers your question properly. Have a great day :D
How is neurons similar to a blood cell
Answer:
A blood cell carries Hemoglobin. A neuron doesn't have hemoglobin, and uses other proteins.
Explanation:
Red blood cells carry a specific type of protein, called hemoglobin, which is able to bind oxygen and release it in other tissues. A nerve cell doesn't have this protein because it doesn't need to bind oxygen. Instead, the nerve cell uses other proteins that help it transmit signals to other cells.
Answer:
Neurons are surrounded by a cell membrane.
I just chocked on a hot cheeto, and my throat hurts. 0n0
Explain one rule of Ultimate Frisbee.
Answer:
The object of Ultimate Frisbee is to gain points by scoring goals. The disc may only be passed, and a goal is scored when a player successfully passes the disc to a teammate in the end zone which that team is attacking. The team with the most points at the end of the game is declared the winner.