long-term management of moderate-to-severe atopic dermatitis with dupilumab and concomitant topical corticosteroids

Answers

Answer 1

For a year, dupilumab was added to the usual topical corticosteroid regimen to ameliorate the signs and symptoms of atopic dermatitis while maintaining tolerable safety.

What is atopic dermatitis ?

It's a chronic illness that occasionally flares up. The signs are diverse. Dr. Davis: Oval or circular patches of skin that are red, weepy, crusty, itchy, and flaky are typical of atopic dermatitis.

A combination of immune system activity, genetics, environmental factors, and stress contribute to the development of eczema (atopic dermatitis). your defence mechanism. Your immune system overreacts to minor irritants or allergens if you have eczema. This overreaction may cause skin inflammation.

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Related Questions

Based on your understanding of Darwin's Theory of Evolution, which of the following organisms would potentially evolve the fastest ?

A) All of these species would have roughly the same rate of evolutionary change

B) A species of roundworm that reproduces via asexual reproduction but contains a DNA replication machinery that introduces 3-6 mutations every mitotic cycle with a generation time of 6 days

C) A species of mammal that reproduces sexually and passes on roughly 3 mutations every generation with a generation time of 18-20 years

D) A species of bacteria with a poor DNA replication error correction capability that normally reproduces asexually but can reproduce sexually and has a generation time of 45 minutes

Answers

Based on Darwin's Theory of Evolution, a species of bacteria with a poor DNA replication error correction capability that normally reproduces asexually but can reproduce sexually and has a generation time of 45 minutes might be the fastest to evolve (Option D).

How does evolution occur?

The process of evolution means descendence with modification involving changes (adaptations) that are adaptive for the individual, which in this case is better represented by sa pecies with a higher mutation rate, fast generation time, and the possibility to perform sexual reproduction to combine adaptive features.

In conclusion, Based on Darwin's Theory of Evolution, a species of bacteria with a poor DNA replication error correction capability that normally reproduces asexually but can reproduce sexually and has a generation time of 45 minutes might be the fastest to evolve (Option D).

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4.2.4 Quiz: Air Head
Question 10 of 10
What is the term for the percentage of light reflected by something?
Answer here
SUBMIT

Answers

Answer: An albedo

Explanation:

The explanation is defined by the amount of light reflected off of a body or surface. The answer and question sort of copy/piggyback off of each other. Good luck !

How many turns of the calvin cycle are required to produce one molecule of glucose?.

Answers

Answer:.......................==========================

Explanation:

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Answer:a;sodihf;aoisdhfo;a ihdfoiahjsdo;ifa;oisdhjf;oaihjsd

Explanation:

What nutrients are found in animal waste? how large a part of the ecosystem are these wastes?.

Answers

Heat is one energy kind that is released. Animal excrement requires some energy to create. Decomposers disintegrate extinct creatures and biological waste. As, the dung beetle is returning to its nest while rolling a ball of dung (animal waste). The excrement will be used by the beetle to feed its young. On a dead log, there are mushrooms growing. They'll disassemble it gradually. As a result, the earth receives its nutrients.

Ecosystem: what is it? What function does animal waste serve there?

A group of living beings and their surroundings make up an ecosystem. Ecosystem is a shortened form of "ecological system." An ecosystem is made up of components that work together, much like any other system.

There are living organisms that contribute to every ecosystem. Food is produced by plants using sunlight. Plants may be consumed by other living beings to gain energy.

Producer 

Living entities called producers to use energy to create food. Food is produced by e-producers.

Consumers 

People cannot prepare their own food. People must consume other living things. They may consume both vegetation and animals. An enormous amount of energy is lost at every stage of the food chain. Only 10% of the energy moves on to the next level. Heat is one kind of energy that is released.

Animal excrement requires some energy to create. Energy is also used to grow items like fur that are inedible to other consumers. The reason why most food chains only have a few tiers is that so much energy is lost.

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A cattle rancher has a trailer full of new Angus feeder cattle to add to
his operation. All the cattle have been taken off the same field and
they are all similar in weight and confirmation. Before he adds them
to his operation he wants to know what will make them gain the
most weight for the least cost. He has an irrigated field with grass, a
barn full of grass hay and barrels of grain. Help him decide what feed
to use.
1. In the above paragraph underline the question or problem.
2. Develop an overview for an experiment to test the problem. Include the steps you will take.
3. Write a Hypothesis of the outcome of the experiment.
4. What is the dependent variable
5. What is the independent variable
6. What is the control/constant.
7. Are the variables qualitative or quantitative? Why?
8. Identify possible sources of unavoidable experimental error.

Answers

The following are the required responses;

1) The problem is to determine what will make them gain the most weight for the least cost.

2) In this experiment, he needs to randomly divide the new cattle breed into three groups and have them feed on an irrigated field with grass, a

barn full of grass hay and barrels of grain.

3) The hypothesis is that the cattle fed on a barn full of grass hay has the greatest weight gain.

4) The dependent variable is the weight of the cattle

5) The independent variable is the type of  feed given to the cattle

6) The constant is the specie of the cattle.

7) The variables are qualitative because they are not countable or numerable.

8) An unavoidable source of error is the estimation of the degree of weight gain which may be done subjectively.

What is an experiment?

An experiment is often used to show the relationship between the independent and the dependent variable. In this case, a cattle rancher has a trailer full of new Angus feeder cattle to add to his operation. All the cattle have been taken off the same field and they are all similar in weight and confirmation. Before he adds them to his operation he wants to know what will make them gain the most weight for the least cost.

1) The problem is to determine what will make them gain the most weight for the least cost.

2) In this experiment, he needs to randomly divide the new cattle breed into three groups and have them feed on an irrigated field with grass, a

barn full of grass hay and barrels of grain.

3) The hypothesis is that the cattle fed on a barn full of grass hay has the greatest weight gain.

4) The dependent variable is the weight of the cattle

5) The independent variable is the type of  feed given to the cattle

6) The constant is the specie of the cattle.

7) The variables are qualitative because they are not countable or numerable.

8) An unavoidable source of error is the estimation of the degree of weight gain which may be done subjectively.

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describe extrinsic factors that regulate growth of eukaryotic cells, including growth factors, cell density, and changes in cell shape.

Answers

Extrinsic cell components are characteristics linked to micro-environmental changes that affect its phenotype and disrupt the progression of neoplastic disease in eukaryotic cells.

What are extrinsic factors?

Extrinsic factors influences are hypothesized to impact several genes at once, but little information has been done on the molecular causes of this extrinsic variability.

They expand by utilizing the biological processes of their hosts to replicate their genetic material.

Demonstrates how regulatory networks can cause extrinsic noise at a target gene's output by converting noise in the expression of upstream regulators.

Our findings highlight the importance of the interaction between gene regulatory networks and population variation for understanding the cell density and cell shape.

Therefore, extrinsic factors that regulate growth of eukaryotic cells.

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A group of animals in the same species is called what?
A) Ecosystem
B) organism
C) community
D) population

Answers

Answer: D)population

Explanation:

A team of scientists and engineers is working together to develop a new cleaning product. The team has identified a species of bacteria that gets energy by breaking apart lipids and oils. The team wants to isolate the key substance that the bacteria use for this process, and then adapt the substance for the new cleaning product.

A. A lipid or oil that is unique to the bacteria

B. A carbohydrate that is about the same size as a typical lipid or oil molecule

C. A nucleic acid that codes for the production of a lipid or oil

D. A protein enzyme that specifically binds lipids or oils

Answers

D. A protein enzyme that specifically binds lipids or oils

The macromolecule to be isolated for this process is a protein break apart lipids and oil.

In the provided question, bacteria obtain energy for their personal metabolic activities by dissolving lipids and oils. This is only feasible due to the bacteria's genetic features. Because all genetic characteristics are coded for by a protein, the scientists must scan the bacterium genome and identify the protein responsible for this function.

Some microorganisms have been utilized in biotechnology due to their value to human endeavours. The majority of probiotics used in the manufacturing of yoghurt are bacteria that are widely recognized as harmless (GRAS). However, the significance of these creatures is extensive.

Because carbohydrates and lipids are not the functional units of genetic expressions, answers a and b are erroneous. Nucleic acids are part of the genetic material, but they are eventually translated into protein. As a result, response choice D is the right one.

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drugs classified as depressants typically a) speed up metabolism. b) slow down neural transmission and behavior. c) increase the likelihood of the sympathetic nervous system becoming active. d) act as antagonists that block the effect of gaba.

Answers

Answer:

B

Explanation:

Depressants slow down neural activity/transmission. They are often used to relieve depression/anxiety/stress/pain for a period of time.

Drugs classified as depressants typically will slow down neural transmission and behavior. Thus, option B is correct.  

What are depressants?

Drugs classified as depressants typically will slow down neural transmission and behavior. Analgesia has been known as the analgesic drug which has been used as a pain reliever or it has been also known as painkiller. The group of drugs that used to relief severe pain has been known as the analgesia. The side effects of the analgesia has that the long term use of analgesia can cause damage to liver and kidney.

There are several conditions in which analgesia are analgesic are given and these are after the surgery, if someone gets injured in case of pain and it is also given in case severe headache. The menstrual pain can also be reliefed by taking analgesia.

Therefore, Drugs classified as depressants typically will slow down neural transmission and behavior. Thus, option B is correct.  

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based on your hypothesis, you predict that the chemical isolated from the fungus will successfully kill cancer cells. to test this prediction, you design the following experiment.

Answers

A hypothesis is an educated guess that could explain an observation.

What is a hypothesis?

A hypothesis is an educated guess that could explain an observation. It is usual that we make a hypothesis when we are trying to solve a problem. Looking at the graph, we can now tell the statements that follow.

Statements supported by the data;

Cancer cells treated with the chemical have a lower survival rate than cancer cells not treated with the chemical.After five days of chemical treatment, less than 50% of the cancer cells are alive.

Statements not supported by the data

Cancer cells treated with the chemicals have a higher survival rate than cancer cells not treated with the chemicalsThis chemical will be useful for treating colon cancer but not other types of cancerThis chemical would be useful for treating all types of cancersAfter 10 days without chemical treatment, more than 90 percent of the cancer cells are alive.

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Many soil-dwelling bacteria produce molecules that can be naturally synthesized and kill other species of bacteria. What are these bacteria-killing molecules called?.

Answers

Many soil-dwelling bacteria produce molecules that can be naturally synthesized and kill other species of bacteria. What are these bacteria-killing molecules called antibiotics

Antibiotics are effective pills which can be usually safe. Although they are very helpful in fighting disease,  antibiotics can actually be harmful. Important Facts About Antibiotic Safety: Antibiotics can cause side effects such as allergic reactions and severe and potentially life-threatening diarrhea caused by the bacterium Clostridium difficile (C. diff).

Antibiotics can also interfere with other medications you may be taking. Antibiotic side effects account for nearly one-fifth of  emergency room visits. These conditions are the most common reasons for emergency room visits for children under the age of 18. Taking antibiotics you don't need unnecessarily exposes you  to the drug's side effects and denies you the benefits.

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Which of the following is the best definition for data?
a. Observations that may be quantitative or qualitative
b. A tentative, testable scientific explanation
c. Useful for determining the effect of the independent variable
d. A logical interpretation based on prior knowledge

Answers

If I had to guess I would go whit D. A logical interpretation based on prior knowledge

the structure of lipids is group of answer choices dominated by hydrophobic regions. dominated by hydrophilic regions. equally dominated by hydrophilic and hydrophobic regions.

Answers

The structure of lipids is "dominated by hydrophobic regions".

Any organic molecule that seems to be soluble in oil or fat but not in water would be a lipid. They serve as energy-storing molecules as well as chemical messengers and include fats, waxes, oils, hormones, as well as some membrane components.

Lipids are often hydrophobic despite being amphiphilic molecules, having all these components of hydrophilic as well as hydrophobic areas within the molecule. This is partly because of the high amount of hydrocarbons in polar regions.

The most abundant membrane lipids are the phospholipids. These have a polar head group and two hydrophobic hydrocarbon tails.

The question is incomplete , the complete question is:

The structure of lipids is group of answer choices :

(a)dominated by hydrophobic regions.

(b)dominated by hydrophilic regions.

(c) equally dominated by hydrophilic and hydrophobic regions.

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a plant disease is any condition in a plant caused by living and nonliving agents that interferes with its normal growth and development.

Answers

The answer is true.

What is a plant disease?

"Anything that inhibits a plant from performing to its maximum potential" is the definition of a plant disease. The scope of this term covers both biotic and abiotic plant diseases.

Field crop-damaging plant diseases are of enormous economic significance, which justifies the widespread and regular use of pesticides. In addition to more typical methods of crop plant infection, agricultural use of BW also has the potential to introduce diseases and weed seeds. In general, the inactivation kinetics of plant pathogens in various hygiene treatments for BW are the same as those for diseases that affect people and animals. But fungal pathogens can produce dormant spores, wait for better circumstances, and live for many years in the soil. They also exhibit a fair amount of resistance to various forms of treatment. Some of them may also house a wide range of plant species. Additionally, some plant viruses, such as the tobacco mosaic virus, are difficult to inactivate with heat.

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Look at the graph to the right. During which 500 meter interval does the temperature decrease most rapidly?​

Answers

Answer:16 degrees

Explanation:

new green fluorescent protein genes for plant transformation: intron-containing, er-localized, and soluble-modified

Answers

The first fully in vivo reporting systems useful in whole plants is GFP, and we predict that when improved GFP genes become available, its utility will grow even more.

What is Gene?

The term "gene" has a variety of meanings in biology. The molecular makes up a gene of DNA nucleotides that are transcribed to generate a functional RNA, while the Mendelian gene is the fundamental unit of heredity. Genes that code for proteins and noncoding genes are the two different categories of molecular genes.

DNA is first replicated into RNA during gene expression. A protein that fulfills a function can be directly generated from the RNA or it can serve as the intermediary template. Phenotypic qualities are passed down through gene inheritance from an organism to its progeny. Different DNA sequences known as genotypes are made up of these genes. The phenotypes are determined by the genotypes as well as by environmental and developmental variables.

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which type of membrane protein attaches cells to other cells? channel linker transporter cell identity marker

Answers

The type of membrane protein that attaches cells to other cells is commonly known as a linker (Option B).

What is a cellular linker?

A cellular linker is a type of protein used to bind cells in a given tissue, thereby having structural functions that are fundamental for the integrity of different tissues.

In conclusion, the type of membrane protein that attaches cells to other cells is commonly known as a linker (Option B).

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Enzymes provide a site where reactants called substrates can be brought together in an enzyme-catalyzed reaction. The site is called the.

Answers

In an enzyme-catalyzed reaction, reactants known as substrates can be brought together at the site provided by enzymes. It functions as an active site.

The area of an enzyme's active site where substrate molecules attach and undergo a chemical reaction is known as the active site in biology and biochemistry.The active site is made up of amino acid residues that catalyze a reaction of that substrate as well as residues that establish temporary bonds with the substrate (binding site) (catalytic site).A binding site is a spot on a protein, piece of DNA, or piece of RNA where a ligand can attach. Proteins are enzymes.An enzyme's active site is a location where substrates can attach to initiate a chemical reaction.The active site of an enzyme is where substrate molecules bind and catalyze the reaction that results in the generation of certain products, whereas the allosteric site is where activator or inhibitor molecules can bind to the enzyme and either activate or inhibit enzyme activity.

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The nuclei of both 3h and 3he have radii of 1. 5×10^−15m. With what velocity must the electron be ejected if it is to escape from the nucleus and not fall back?.

Answers

The velocity with which the electron must be ejected to escape from the nucleus and not fall back is 8.21067 x 10^8 m/s.

How the electron of the nucleus and with what velocity it must move to not fall back?According to the question provided, we know that 3H and  3E ( radii = 1.5 x 10^-15m) .We use the concept of escape velocity.Kinetic energy, K.E. = 1/2 mv^2 = P.E.1/4piEo x q1xq2/r = K xq1 xq2/r Equating the both we get 1/2mv^2v= sqrt ( 1/pi x Eo)(e^2/mxr)v=sqrt(1/pix8.85x10^-12)(1.602x10^-19)(9.11x10^-31x1.5x10^-15m)v=8.21067x10^8 m/s.

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Why might energy be needed to assist in molecules moving across a cell membrane?.

Answers

Energy be needed to assist in molecules moving across a cell membrane because transport occurs against the concentration gradient .

The transport in the cell occurs through the cell membrane by different mechanisms like active transport and passive transport in order to enter nutrients and eliminate waste .

There are lots of molecules which can pass through the cell membrane without any difficulty but there are some other molecules also requires energy to enter into the cell membrane due to their structure , chemical composition , hydrophilic or hydrophobic properties .

Active transport :

in this type of transport force is developed . it requires energy to carried out the transportation because it is a type of movement which involves the transport of molecules against concentration gradient i.e. from lower concentration to the higher concentration . it carried out through pumps.

Cell membrane :

It is also known as plasma membrane . it is defined as a living , ultrathin , dynamic , elastic semipermeable membrane that encloses the protoplasm of a cell .

It is the outer most boundary of all living cells . but prokaryotes and plant cells generally have an additional cell wall outside the plasma membrane.

Plasma membrane of neuron is called neurolemma while that of haemolysed RBC is called red cell ghost . the plasma membrane of muscle cell along with based lamina is called sarcolemma .

Along with plasma membrane , the eukaryotes also contains intracellular membrane surrounding the vacuole and organelles . the plasma membrane and the intracellular membranes together called as biological membranes of bio-membranes.

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Which of these factors may affect nutritional needs? Select three options.

Answers

Answer:

Age, activity level, pregnancy

Explanation:

what property of water allows it to move from the roots, to the leaves of plants

Answers

Answer:

The cohesive properties of water

Explanation:

The cohesive properties of water (hydrogen bonding between adjacent water molecules) allow the column of water to be 'pulled' up through the plant as water molecules are evaporating at the surfaces of leaf cells. This process has been termed the Cohesion Theory of Sap Ascent in plants.

who coined the phrase ""nature versus nurture"" to convey the question of whether genes or upbringing has the most significant effect on developing humans? a) alfred binet b) raymond cattell c) theodore simon d) sir francis galton

Answers

Option D: Sir Francis Galton coined the phrase "nature versus nurture".

The term 'nature' refers to the effect of genes on one's characteristic traits while the term 'nurture' refers to the effect of upbringing of a child on its characteristic health and other conditions. This is a well-known scientific fact that we acquire traits and inborn health conditions through genes from our parents. These are generally termed genetic traits.

But it is now known that environmental factors can affect your chances to acquire these significant health conditions from your parents. If you are at a risk to get diabetes through genes from your parents, you may adopt a healthier diet and exercise regularly to avoid the adverse health conditions. Also, if the environment is kept negative the child is likely to get depression or mental disorders.

Sir Francis Galton while discussing whether genes or upbringing has the most significant effect on developing humans coined the phrase "nature versus nurture". He particularly referred to genes through nature and one's upbringing environment through nurture.

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the is the most complex region of the brain. a. forebrain b. midbrain c. hindbrain d. brainstem please select the best answer from the choices provided a b c d

Answers

The most complex region of the brain is forebrain. Forebrain have cerebrum which is the largest and complex part of brain.

What is brain?

Brain is the central organ in the human system. It is divided into three parts such as forebrain, midbrain and hindbrain. It is the commanding center in the body.

The human brain along with spinal cord makes up the central nervous system. Corpus callosum contains two hemispheres of brain.

Forebrain is the most thinking part and it controls the voluntary actions. It is consist of cerebrum, thalamus and hypothalamus. Midbrain connects the forebrain and midbrain. It contains cerebellum which maintains equilibrium in the body.

Therefore, The most complex region of the brain is forebrain. Forebrain have cerebrum which is the largest and complex part of brain.

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If a force of 18N is exerted over a 2m² area, how much pressure is there?

Answers

The pressure is found to be 9 Pascal.

Given here the force = 18N and Area where the force applied is 2m².

So pressure can be calculated as,

Pressure = Force/Area

Pressure = 18/2 = 9pa.

This, the pressure is found to be 9pascals.

The force delivered perpendicularly to an object’s surface per unit area across which that force is dispersed is known as pressure. Pressure has various units, the most common units are Pascal and newton per square meter. Pressure is a scalar quantity.

Different instrument used to determine pressure are barometer, pressure gauge (used to measure the condition of a gas or fluid). Manometers are used to measure pressure, which is the force a gas or liquid exerts per unit surface area as a result of the gravitational influences on its weight. This kind of manometer is known as a sphygmomanometer.

Different formula are present to determine pressure, they are:-

Pressure =Force /Area

Pressure = Work / volume

Pressure = Energy / volume.

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Decomposers, detrivores, and scavengers feed on dead organic material. How are decomposers different from scavengers and detrivores?.

Answers

Decomposers chemically break down dead material while Detritivores and scavengers physically alter it by chewing and tearing.

Detritivores are those organisms that feed on decaying and dead matter. They degrade different types of value/organisms directly through digestion.

Examples of Detritivores include crabs, worms, millipedes, flies, etc.

On the other hand, decomposers secrete specific enzymes to decompose dead and decaying organic matter.

Examples of decomposers include bacteria, fungi, and other insects.

While scavengers are those organisms that eat the meat of dead animals and rotting plant material, they only break down the food in digestion but do not alter their physical state like decomposers.

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effect of different feeding schedules on the survival and neural differentiation of human embryonic and induced pluripotent stem cells

Answers

The survival or neuronal development of human embryonic or human induced pluripotent stem cells is not improved by feeding them more than five days per week.

Why does feeding not increase neuronal differentiation or cell survival?

An induced pluripotent stem cells (iPSCs) and embryonic stem cells (ESCs) can differentiate into any form of specialized human cell, ESC/iPSC-derived cell types have a lot of potential for use in regenerative medicine.

Neuroscience research can benefit from neural culture of human pluripotent stem cells. However, it is unknown what the ideal feeding schedule for these in vitro systems should be. Human embryonic and induced pluripotent stem cells were cultivated with medium exchange schedules of five, six, or seven days per week during two months of differentiation. We assessed the survival and neural differentiation characteristics of these cells. Through this period of culture, neither human pluripotent cell type showed any appreciable alterations in cell counts or indicators of brain development. We come to the conclusion that feeding this culture system more than five days a week is unlikely to be advantageous.

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Dark pocket mice are found in locations that have dark substrate. genetics revealed what surprising fact about mice in different locations? a. they had different mutations b. they had the same mutations c. they were not related

Answers

The surprising fact about mice revealed by genetics is that they have the same mutations.

How come dark pocket mice have same mutations?Dark pocket mice have mutations happening in same gene.It is already known that dark pocket mice better adapts in dark that is black substrate or black ground.Likewise brown mice will better adapt in the regions of sand or soil.What actually happens is if a mice have darker fur or darker color then it will have the opportunity to better survive in the darker regions.And the darker the environment , the darker the fur so the better survival , all these comes from mutation . If the mutation rate would be greater then it will more environment friendly.

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the sodium-potassium pump helps to maintain the concentration gradients for sodium and potassium ions across the plasma membrane. select the true statement regarding the sodium-potassium pump.

Answers

For every ATP molecule used by the pump, three sodium ions with positive charges are removed from the cell.

ATP- Adenosine 5′-triphosphate, generally known as ATP and typically written without the 5′-, is an essential "energy molecule" found in all living organisms. In specifically, it is a coenzyme that, when it interacts with enzymes like ATP triphosphatase, releases its phosphate groups, transferring energy to cells.

Coenzyme- Many enzymes need coenzymes, which are organic substances, for catalytic action. They frequently include vitamins or vitamin compounds. They can occasionally serve as catalysts in the absence of enzymes, however not as efficiently as when an enzyme is present.

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Which of the following statements is correct about these amino acids?

Answers

Answer:

C

Explanation:

something needs to be polar to diffuse through the plasma membrane, which the first aa is on the outside

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