Li-Fraumeni syndrome (LFS1) is a rare hereditary disorder that leads to a predisposition to cancer. This hereditary disorder is linked to mutations in the tumor suppressor gene encoding the transcription factor p53. p53 acts at the G1 checkpoint. If damaged DNA is detected, p53 halts the cell cycle. As p53 levels rise, the production of p21 is triggered. p21 enforces the halt in the cell cycle. A variant of Li-Fraumeni, called LFS2, is thought to occur due to a mutation of the CHK2 gene, which is also a tumor suppressor gene. CHK2 regulates the action of p53. Which of the following cascades is most likely to occur in a normal cell that does not contain the LFS mutation?

Answers

Answer 1

Answer:

CHK2, p53, p21, cell cycle progression.

Explanation:

In a normal cell with no LFS mutation, during the G1 stage of cell cycle progression, the CHK2 activates if there is damage in the DNA. CHK2 activates p53, which is a tumor suppressor protein that will hold the cell cycle in G1/S until the DNA is repaired. The p53 protein activates p21, a protein that binds to CDK2 and stops the cell cycle. The cell cycle will continue once the damage is repaired.      


Related Questions

DUE BY MIDNIGHT. Just need to make sure it’s correct.

Answers

Answer:

Yes, it is correct, but you should also specify that B stands for black and b stands for gray, it is also important to mention the characteristic in order to have full information.

1. An anthropologist lives with the Kpelle (pronounced pe-lay) of West Africa. He writes about what it felt like to live in the Kpelle community. He makes many friends with members of the community while doing his research. Whenever he can, he seeks to understand how his friends feel about the events of their day-to-day lives. When he returns back to Las Vegas, he writes a book emphasizing his friends' points of view. He tries to write the book so that, if his Kpelle friends read the book, they would understand the situations and feelings he is talking about. What kind of anthropology is he performing? Mark all that apply.

- Humanistic anthropology

- Linguistic anthropology

- Scientific anthropology

- Cultural anthropology

- Archaeology

2.A method where the researcher lives with a group of people and studies all aspects of their way of life is called:

A. Deception Study

B. Quantitative analysis

C. Participant Observation

D. Focus Group

E. Study Instrument

Answers

. . . . . . . . . . .
Djckcifjjdjcjcjcjcjjddici

color indicator of calamansi

Answers

Litmus paper turns red or pale red in calamansi juice. Litmus paper turns red in acids and blue in bases. Litmus paper is a natural indicator. One property of acids is the sour taste, and calamansi juice is an acid.

Drag each item to indicate pros and cons of using the reverse osmosis method to filter water.

Answers

Answer:

Pros:

Requires minimal maintenance

Removes all types of contaminants to some extent

Con:

Lowers the pH of the water making it more acidic

Has limited or no flow rate due to small pore size

Explanation:

Took the test and I got  this was right.

Reverse osmosis is a purification technique for water which remove unwanted ions from water through the process of osmosis

What is reverse osmosis?

Reverse osmosis is a process of using osmosis to separate unwanted ions and sediments from water through a semi-permeable membrane.

The benefits of reverse osmosis include:

is very simple to set uprequires minimal maintenanceremoves most contaminants

The disadvantages of reverse osmosis include:

it is time consuming it lowers pH of water making it acidic

Therefore, reverse osmosis is a purification technique for water which remove unwanted ions from water through the process of osmosis.

Learn more about reverse osmosis at: https://brainly.com/question/14695461

#SPJ2

5. Scientists have studied glaciers in Greenland as evidence of global warming. One team of scientists predicts that glaciers are melting at an accelerated rate. The scientists collect the same types of data on the same glaciers on the same dates each year for ten years. The scientists conclude that the glaciers have decreased in mass and increased their velocity toward the sea each successive year. Which of the following statements best evaluates the process that the scientists used? The process is a flawed experiment because the variables are not controlled. b. The process is a valid experiment because there is an independent variable and a test variable. The process is a flawed investigation because the investigators did not begin by forming a hypothesis. d. The process is a valid investigation because scientists used systematic methods for collecting and analyzing information. C.​

Answers

answer:

D.

Explanation:

hope it helps!!!!!!!!!!!!!!!

Answer:

d the process is a valid investigation because scientists used systematic methods for collecting and analyzing information

PLZ HELP THIS IS URGENT
15 POINTS!!!!
WILL GIVE BRANLIST IF THERE ALL RIGHT!!!!
PLZ HELP I HAVE 2 HOURS TO TURN THIS IN!!!



Classify each as a carbohydrate or lipid. 1.carbohydrate
2.lipid

unsaturated fat

phospholipid

triglyceride

steroid

glucose

polysaccharide

starch

cellulose

2.
Classify each as a carbohydrate or lipid.

phospholipid 1.carbohydrate
2.Lipid
forms the cell membrane of all cells

cholesterol

animal and plant structures

provides long-term energy storage for animals

provides immediate energy

one sugar

Answers

Answer:

Glucose, a sugar, has a ring of carbon atoms and one oxygen atom. ... Carbohydrates are classified into three subtypes: monosaccharides, disaccharides, and polysaccharides. ... Starch, glycogen, cellulose, and chitin are examples of polysaccharides. Starch ... Lipids include fats, oils, waxes, phospholipids, and steroids.cholesterol phospholipid glycerol steroid monosaccharide. 1. Carb. 2. lipid. 3. ... provides long-term energy storage for animals ... provides immediate energy ... animal and plant structures forms the cell membrane of all cells ... lowering activation energy one sugar. 17. lipids. 18. Protein - Amino Acids. 19. Carb. - Sugar. 20.

Explanation:

Glucose, a sugar, has a ring of carbon atoms and one oxygen atom. ... Carbohydrates are classified into three subtypes: monosaccharides, disaccharides, and polysaccharides. ... Starch, glycogen, cellulose, and chitin are examples of polysaccharides. Starch ... Lipids include fats, oils, waxes, phospholipids, and steroids.cholesterol phospholipid glycerol steroid monosaccharide. 1. Carb. 2. lipid. 3. ... provides long-term energy storage for animals ... provides immediate energy ... animal and plant structures forms the cell membrane of all cells ... lowering activation energy one sugar. 17. lipids. 18. Protein - Amino Acids. 19. Carb. - Sugar. 20

11. The random movement of particles like O2, CO2, or H2O across the membrane is called...________________.

Answers

Answer:

diffusion

Explanation:

these particles are in gases and so gases move from an area of high concentration (outside membrane) to an area of low concentration down a concentration gradient

4. In which International Metric units are length measurements expressed?

Answers

Answer:meters

Explanation:

Pure liquid water has pH of 7 which means that water is

Answers

Answer: neutral

Explanation: The range goes from 0 to 14, with 7 being neutral. pHs of less than 7 indicate acidity, whereas a pH of greater than 7 indicates a base. pH is really a measure of the relative amount of free hydrogen and hydroxyl ions in the water.

Answer:

pH is a measure of how acidic/basic water is. The range goes from 0 to 14, with 7 being neutral. pHs of less than 7 indicate acidity,

Explanation:

hope this helped :)

Which statement describes an action-reaction pair?
A. You push on the ground when you sit down, and the ground
pushes up on you.
B. You add mass to agboat
, and the boat sinks lower in the water.
C. You apply the brakes in your car, and the car slows down.
D. An astronaut is pulled in one direction by Earth and in the opposite
direction by the Moon.
SUBMIT

Answers

Answer:

A:you push on the ground when you sit in the ground

Explanation:

iddkkkkkkkkkkkkk

Which of the following would be considered a competitor or Corals and a direct threat to coral reefs?
Zooxanthellae
Green Algae
Crown of Thorns Sea Star
Coralline Red Algae
Rainbow Parrot Fish

Answers

Answer:

Rainbow Parrot Fish

Explanation:

Rainbow Parrot Fish is an herbivore and it is considered as competitor of corals and a direct threat to coral reef because Rainbow Parrot Fish majorly source of feed is algae which result in missing of lots of algae in corals colony. They consume most of the coral in the coral reefs with their beak like teeth therefore resulting in competition and not enough available algae source for corals. After feeding on algae , they also graze on corals in Coral reefs.

Natalia is good at drumming, dancing, and tasks that require precise rhythm judgment. Which part of her brain is likely to be well developed?

Answers

Hey , my names Natalia......

Anyways JESUS LOVES YOUUUU!!!!!❤️❤️❤️❤️❤️❤️❤️

10pts PLZ HELP DUE IN 2 HOURS!!

Answers

C - Organic Molecules. Most carbon-based molecules are called organica molecules.

A is wrong because inorganic molecules are non-carbon-based, and carbon based molecules are not ions, so B is wrong too. D is wrong because macromolecules is does have carbon, as every living thing, but macromolecules is not another name for carbon based molecules, Therefore organic molecules is the answer.

What is the relationship between the carrying capacity and limiting factors of a population?
A. The size of a population is its carrying capacity, which is set by limiting factors such as predators.
B. Limiting factors often prevent a population from growing above its carrying capacity for long.
C. A population with no limiting factors would have a carrying capacity of zero.
D.Carrying capacity is a biotic factor, while limiting factors are abiotic factors.​

Answers

The answer is B. Limiting factors often prevent a population from growing above its carrying capacity for long.

Aquarium salt water is prepared to a salinity of 30 ppt (parts per trillion) by dissolving 3.26 kg of salt into 114 L of water. If you wanted to make 4,000 mL of salt water at the same salinity, how many grams of salt will you need?

Answers

Answer:

114 gram of salt is required.

Explanation:

Below are the following given data in the question:

Prepared salinity water = 30 ppt

Weight of salt used = 3.26 kg

The volume of water = 114 L

Below is the calculation.

4000 mL = 4000/1000 = 4L

Let the used = x kg

3.26/114 = x/4L

Now solve for the x.

x = 0.114 kg or 114 gram

In parts of the Northern Hemisphere grasslands, the spring growing season is becoming two weeks longer than in the second half of the 20th century. The spring growing season is now coming earlier in both hemispheres. Based on the above statement and the following graph, what conclusion can be made regarding temperature?​

Answers

Answer:

Natural Earth cycles result in increased temperatures    

Explanation:

By temperature looking te the graph we can see that there is a soft increase in temperature from 1880- 1940. It seems that from 1940-1980, the temperature was stable, but since 1980 there is a noticeable temperature increase, until the year 2000. By year there are increases and decreases in temperature, which correspond to the different seasons and temperature cycles over the year, but in a general vision, the temperature is obviously increasing with the pass of years.

According to the statement, the spring growing season is becoming longer than in the second half of the 20th century, and it is coming earlier. This is reflected in the graph from the year 1980 to 2000.

According to the graph and the statement, we could estimate what is going to happen in the next years is there is no change. Although, we can not predict it for sure.  

Which of the following correctly completes the table?
A, A=DNA or RNA, B=cell fuel and support, C=galactose and glycogen, D=nucleic acids and fatty acids
B,A=DNA or RNA, B=cell fuel and support, C=galactose and glycogen, D=nucleic acids and fatty acids
C, A=fructose and lipids, B =cell control and fuel, C=enzyme and catalyst, D=nucleotides and myosin
D, A=hemoglobin and insulin, B=cell control and reproduction, C=deoxyribose and ribose, D=sugars and lipids

Answers

Well the good thing is, the correct answer is here, the bad news is it appears twice but I believe that is a mistake?
The correct answer is A or B, they’re the same thing but they are the correct answers

PLEASE HURRY Which mutation results in the production of molecules that can be used as a source of energy?

a mutation that causes bacteria to fight off antibiotics

a mutation that breaks down the sugar in milk, lactose

a mutation that changes the color of a part of a flower

Answers

Answer:

It is the second one.

Explanation:

I know for a 100% chance because I just finished this test and got a 100.

Answer:

B.(a mutation that breaks down the sugar in milk, lactose)

Explanation:

What specialized structure would you expect to find in a cell adapted to
produce energy?
A. Lysosome
B. Chloroplast
C. Mitochondrion
D. Nucleus

Answers

The answer is Mitochondria

Comprehensive Biology What process is used in this example?

Cells come from pre-existing cells. Cells pass genetic information as DNA via reproduction. DNA carries the blueprint for life. Changes in the blueprint lead to changes in living things. Therefore most biologists assume that all living things had a common single-celled ancestor 3.5 billion years ago.​

Answers

Answer:

The answer is b

Explanation:

CONCLUSIONS: Genetic counseling is useful in predicting the probability of a child being born with a Mendelian inherited trait. Sickle cell anemia is caused by a recessive allele. A couple would like to know the chances of their child having sickle cell anemia. Parent #2 has the disease; parent #1 does not. Based on phenotype, parent #2 would have the genotype, ss. Parent #1 could be genotype, SS or Ss. Punnett Squares have been set up for crosses using both possible genotypes of parent #1. Should the couple be concerned that their child may have sickle cell disease? Why or why not?

Answers

Answer:

Yes, if parent 1 is Ss then there is a 50% chance the child will have it.

Explanation:

explain what surface tension is

Answers

Answer: the tension of the surface film of a liquid caused by the attraction of the particles in the surface layer by the bulk of the liquid, which tends to minimize surface area.

Explanation:

what reason could exist for varying length of beans

Answers

Different soil, location can be a factor, the amount of sun, wild and domesticated can vary

How much do you need to drink?

Answers

About 15.5 cups (3.7 liters) of fluids a day for men. About 11.5 cups (2.7 liters) of fluids a day for wome

The concentration of the solute in the solution is the same as in the cell

Answers

If the solute concentration is equal both inside and outside of the cell it is isotonic

Drag each tile to the correct location not all the labels will be used identify the phases in the lifecycle of small and big stars

Answers

Answer:

Here's an explanation instead:

Explanation:

ALL STARS BEGIN IN A STELLAR NEBULA / NEBULA

Depending on how much mass the star has, it changes what path of life cycle it will take. Low mass or average mass stars become an average star, also called a main sequence star. It swells after millions of years into a Red Giant which is GIANT. Many many many years later, it becomes a planetary nebula, and finally becomes into a white dwarf.

If the star has a large mass, it is classified as a massive star, and also goes through a form of main sequence. It swells into a MASSIVE GIANT TREMENDIOUSLY LARGE AND UNNECCESSARILY BIGGO star called Red Supergiants. After millions and billions of years, it becomes a Supernova, which finally becomes a black hole if the outer layers literally get blown off into space and the core collapses and gets compacted into incredibly dense Nano-Googleplex  sized molecules. If it doesn't, it becomes a cool Neutron Star.

I cannot drag tiles around, because there is no tiles or labels, however, I hope you get the point from this weird answer.

During passive transport, substances travel___The concentration gradient

Answers

Answer:

During passive transport, substances travel with the concentration gradient.

During passive transport, substances travel with the concentration gradient.

What is passive transport?

Passive transport is defined as the type of the membrane transport that has to be required energy that has to move the substances just across the cell membrane. In place of using the cellular energy just like in the process of the active transport as well as passive transport that relies on the second law of the thermodynamics that has to drive the particular movement of the substances just across the cell membranes.

During passive transport, substances travel with the concentration gradient. In place of using the cellular energy just like in the process of the active transport as well as passive transport that relies on the second law of the thermodynamics that has to drive the particular movement of the substances just across the cell membranes. Passive transport is defined as the type of the membrane transport that has to be required energy that has to move the substances just across the cell membrane.

Therefore, Passive transport is defined as the type of the membrane transport that has to be required energy that has to move the substances just across the cell membrane.

Learn more about passive transport here:

https://brainly.com/question/13542102

#SPJ5

of the following biological levels of organization, which represents the smallest or lowest level? A.organs B.populations.c.cells.D.organism

Answers

C. Cells

Cells make up organs, which make up organisms, which make up populations

Answer:

cells

Explanation:

cells are by far the smallest

What is one way homeostasis benefits living organisms?


A. It maintains balance.

B. It reduces air pollution.

C. It increases food
consumption.

D. It regulates atmospheric temperature.

Answers

Answer:

it's a

Explanation:

homeostasis is in an organism so it can't be any of the others

Answer:

The answer is A

Explanation:

Homeostasis is the ability to maintain a relatively stable internal state that persists despite changes in the world outside.

Are acids slippery to the touch ??

Answers

Answer:yes

Explanation:most are liquid

Answer: acids are wet to the touch so more than likely yes

Explanation:

Other Questions
What is the displacement from the forest to the doctors office? Which one is NOT a decimal fraction?32/132/1032/3232/100 Molly is planting the flowers using the proportional relationship of 18 pink flowers to 12 white flowers per row.Find the ratio of pink flowers per white flower per row Write 1/4x-3/4y=-1 in standard formwork outneed asapplease Which of the following belief systems argues that respect for parents and elders is important for social order?ALegalismB.ConfucianismBuddhismDDaoism India's caste system made sure that people:O A. kept the same jobs their whole lives.O B. all had the same rights.O C. could serve in the military if they wanted.D. would only worship one god. Graph the equation. Y=2/3x*2+4x+4 Solve For b show your work 3b+2(b-3)=4Plz show work my brother..... a new job a week ago(got... Get.. Has got) 8.5-(-6.36) = what's the answer please hurry Convert the following: 4.6L(liters) to ml(milliliters).a. 0.46 mlb. 46 mlc. 46,000 mld. 4600 ml List the numbers from greater to least 3/5, 0.56, 75%, 0.8 Which property of addition is shown in the equation below?a + bi + 0 + Oi = a + biA.commutative propertyB.inverse propertyC.identity propertyD.associative property If AABC = ADEC,ZB = 3x and ZE = 6x - 39 can this expression be simplified anymore? It cost Benjamin $1.35 to send 9 text messages. How much would it cost to send 118 text messages? Help me pls Which of the following statements is accurate? a. Stereotypes are a good way to check our perceptions. b Stereotypes can keep us from creating accurate perceptions c. Stereotypes are a convenient way to categorize people d. Stereotypes can help us to create accurate perceptions. Please select the best answer from the choices provided A B C D What is the key to having a long term, sustainable food supply in the new millennium a. heavy equipment useb. hydro podsc. agriculture research d. increased use of pesticides Please solve1/3 (b+6)=1/4b +8 What three things Trump supporters are happy about.