Fibroblasts can be placed on thin sheets of silicone rubber. Under normal circumstances, fibroblasts exert sufficient tension on the rubber so that it visibly wrinkles. Explain how the ability of fibroblasts to wrinkle rubber would change if the cells were treated with a permeable form of C3 transferase, a toxin (from the bacterium Clostridium botulinum) that covalently modifies an amino acid in Rho. The modification renders Rho unable to bind to proteins that it would normally bind to when active.

Answers

Answer 1

Answer:

C3 transferase decreases Rho activity and contractility by decreasing the number of stress fibers and thus also reducing wrinkles

Explanation:

Rho protein is a small GTPase, i.e., an enzyme that binds GTP to hydrolyze it to GDP, which is known to mediate the formation of stress fibers and focal adhesion. Rho protein is involved in diverse cellular functions including, among others, adhesion, motility, and division by reorganization of the actin cytoskeleton. The bacterial toxin C3 transferase derived from Clostridium botulinum is able to lock Rho in an inactive state. C3 transferase adds an ADP-ribose to Rho, thereby leading to the accumulation of a Rho-guanine nucleotide dissociation inhibitor (GDI) complex in the cytoplasm. In consequence, C3 transferase functions to decrease contractility by blocking Rho activity, decreasing the number of stress fibers and leading to a reduction in wrinkles.


Related Questions

what is the difference between primary and secondary active trnsport

Answers

Answer:

In primary active transport, the energy is gotten directly from the breakdown of ATP.  In the secondary active transport, the energy is gotten secondarily from energy that has been stored in the form of ionic concentration differences between the two sides of a membrane

Hurry plz
Biology is . . .
A. a branch of science.
B. a static branch of science.
C. not a diverse branch.

Answers

A

biology is branch of science which deals with life

Answer:

A

A branch of science

Explanation:

Biology is the study of living things(plants and animals) and their interactions with one another and the environment. It deals with the study of life

Which of the following statement is true about recombinant DNA

Answers

Answer:

It combines genes from two different organisms.

The answers are plz help

A: Lipid

B: protein

C: Glycolipid

D: Carbohydrate

Answers

Answer:

protein

Explanation:

Carrier proteins allow moves other materials within the organism.

4. At night a similar event takes place (as that described in #3 above). As the sun goes down,
the air contains a certain amount of water vapor. The air then begins to cool
and eventually the air reaches the dew point. What is the dew point and what would form
at this point?
100points?

Answers

Answer:

its t0 wlsllslseopwpwooop

help ASAP due at 7:30 What explains a broken bone healing?


look at the photo​

Answers

Answer:

1st one

Explanation:

DNA replace the old cells

The use of drugs at a lower level in feeds than would be used to treat a sick animal is referred to as

Answers

It would be known as subtherapeutic use of and to Anti-microbial’s an animal feeds

I need help ASAP pleaseee :( also im in 5th grade btw

Answers

Answer:

Ok I will help you what is the problem

Explanation:

What’s the problem I’m in high school so I can help

NEED HELP ASAP!!!
The coordinated action of two types of myofilaments, actin and myosin, results in muscle contraction. The muscles contract as actin filaments slide over myosin filaments. When the muscle is in a relaxed state, the myosin heads are ready to bind with the actin filament. However, they are not able to bind due to

a.
the absence of ATP

b.
a high concentration of Ca++ ions

c.
blockage of the attachment site

d.
alcoholic fermentation

Answers

Answer:

I think due to absence of ATP but I'm not sure.. Actin and myosin return to their unbound state causing the muscle to relax. Alternatively relaxation (failure) will also occur when ATP is no longer available.

Myosin heads are ready to bind with the actin filament they are not able to bind due to the absence of ATP.

How two myofilaments involved in muscle contraction?

Muscle contraction results from an intercommunication between the actin and myosin filaments which generate movement relative to one another.

What happens to the actin and myosin filaments when a muscle contracts?

Myosin movement appear to be a kind of molecular hop. The myosin reaches forward, binds to actin, contracts, releases actin, and then reaches forward again to bind actin in a new cycle.

What happens to actin and myosin during muscle relaxation?

Relaxation occurs when nerve stimulation stops. Calcium gets moved back into the sarcoplasmic reticulum shattering the link between actin and myosin. Actin and myosin then return to their unbound state causing the muscle to relax.

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Question 4
2 Points
Suppose the total concentration of potassium (K+) in the cell is 10 times less than the concentration of K+ in the
extracellular fluid. The cell would need to use
to move K+ out of the cell.
A passive transport
B
facilitated diffusion
C) osmosis
D active transport

Answers

Answer:

C

Explanation:

Because thex=y so a reverse review is nice to =15

The cactus wren bird
build its nests in the
cholla cactus to help
keep its babies away
from harm. This gids
the cactus wren but
does not harm the
cactus plant.
Which symbiotic relationship is described above?
Parasitism
Mutualism
Commensalism
Coevolution

Answers

Answer:

Commensalism

Explanation:

the wren bird is benefiting but the cactus not benefiting and it isn't being harmed at all

an object weighs 20n it displaces a volume of water that weighs 15n what is the buoyant force on the object

Answers

Answer:

sorry dont no what u say

so bye

Which of these questions could BEST be answered with the methods of science?

a. How is Earth different from other planets?
b. What does it mean to be a good person?

c. Will computers make us more or less human?

Answers

Answer:

A

Explanation:

It is about planets and planets are in space.

AIDS is the fifth and most severe phase of HIV infection

Answers

Answer:

HIV is the virus that causes Aids

last stage is Full blown stage

How are phospholipids and DNA similr

Answers

Answer:

I think answer is liquid vesicles concentration was 0.3 mg/ ml

What happens when the thin filament in a muscle fiber slides over the thick filaments?

Answers

Answer:

As the thin filaments slide inward, structures called Z-discs come toward each other and the sarcomere shortens but the lengths of thick and thin filaments do not change. The sliding of the filaments and shortening of the sarcomere cause shortening of the whole muscle fiber and ultimately the entire muscle.

Answer:

Sliding of the filaments and shortening

Explanation:

As the thin filaments slide inward, structures called Z-discs come toward each other and the sarcomere shortens but the lengths of thick and thin filaments do not change. The sliding of the filaments and shortening of the sarcomere cause shortening of the whole muscle fiber and ultimately the entire muscle.

PLS MARK BRAINLIEST

At what age will most adults experience decreased ROM

Answers

For instance, due to the normal aging process, muscle properties decline about 30–50% between the ages of 40 and 80 years old; this decline may result in reduced range of motion (ROM), reduced muscle strength, and diminished plantar tactile sensation leading to alteration in plantar loading responses3).

Answer:

between the ages of 40 and 80 years old

Explanation:

. How much time does it take a person to walk 12 km north at a velocity of 6.5 km/h

Answers

Answer:

It will take 1.85 hours to walk 12 km north.

Answer:

Explanation:

v=[tex]\frac{d}{t}[/tex]

and the d here is the distance which is equal 12 km

the time is still unknown

and we know the velocity which is 6.5 km/h

and according to the triangle of the velocity "search that up "

t =[tex]\frac{d}{v}[/tex]= [tex]\frac{12}{6.5}[/tex]≈1.8 hours

11. A flower produces a seed. Explain why this is an example of sexual reproduction

Answers

Answer:

itrequires genetic material (DNA) from two parents. The parent plants have male and female sex cells, called gametes. ... Seeds produced through fertilization contain genetic material from both parents.

The production of a seed by a flower is an example of sexual reproduction because it involves the fusion of male and female gametes (pollen and ovules) to form a genetically diverse offspring.

Sexual reproduction is a type of reproductive process that involves the combination of genetic material from two parent organisms, resulting in the formation of genetically diverse offspring. In the case of a flower producing a seed, sexual reproduction occurs through a series of specialized reproductive structures and processes.

Male Gamete Production (Pollen): Flowers produce male gametes, or pollen, in structures called anthers. Pollen contains the male reproductive cells necessary for fertilization. When pollen is mature, it is released from the anthers.

Female Gamete Production (Ovules): Flowers also produce female gametes, or ovules, within the ovary. Each ovule contains an egg cell, which is the female reproductive cell. The ovary is located at the base of the flower.

Pollination: Pollination is the process by which pollen from the male reproductive structures (anthers) is transferred to the female reproductive structures (stigma) of the same or a different flower. This can occur through wind, water, insects, birds, or other means.

Fertilization: Once pollen lands on the stigma of a compatible flower, it forms a pollen tube that grows down into the ovary. This tube delivers the male gametes to the ovules, where fertilization occurs. Fertilization is the fusion of a male gamete with a female gamete to form a zygote, which develops into an embryo within the seed.

Seed Formation: After fertilization, the ovule develops into a seed, which contains the embryo, endosperm, and protective seed coat. The embryo carries genetic information from both parent plants, resulting in genetic diversity.

The combination of genetic material from male and female parent plants results in offspring with unique genetic characteristics. This genetic diversity is advantageous for the survival and adaptation of species to changing environments. Therefore, the production of a seed by a flower is a prime example of sexual reproduction, involving the fusion of gametes to create genetically diverse offspring with traits inherited from both parents.

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How does increasing the temperature affect the random motion of molecules?

Answers

Answer:

Raising temperature increases energy, resulting in faster speed of molecules.

Explanation:

Increasing the temperature introduces more energy to the system, which will cause the random motion of molecules to increase in speed.

Hope this helps! :) Let me know if my answer doesn't make sense!

The cell membrane of an animal cell was damaged, preventing the cell from performing one of its functions. Which cell function would be lost, and how would this loss affect the cell?

Answers

Answer:

ok so

Explanation:

If the cell membrane of an animal cell is damaged, it would lose the ability to take in nutrients and excrete wastes. This would hinder the cell's capacity to create necessary materials and maintain proper functioning. Thus, the correct option is (b).

The correct response is option (b). The transport of chemicals into and out of the cell is regulated by the cell membrane, which acts as a selectively permeable barrier. Essential cell processes like food intake and waste elimination would be impeded if the membrane were to get disrupted.

This would impede the cell's capacity to produce required components through nutrient-dependent processes like metabolism. There would be a significant negative impact on the cell's general health and function, which could result in cellular malfunction, slowed growth, and ultimately cellular death.

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A car is driving 75 miles per hour down the interstate and sees a wreck in the distance. The car starts slowing down, but takes a while until it completely comes to a stop. If the acceleration was 98 miles/hr2, how long did it take for the car to decelerate?

Answers

Answer:

43

Explanation:

Because we need to multiply the product

Question 1: Some cells produce and secrete high levels of digestive proteins. Which organelles would you expect to be abundant in those cells, and why? Question 2: Explain how active transport helps a nerve cell maintain its resting potential. Question 3: The Atlantic cod is a common fish of the Atlantic Ocean that must drink seawater to meet its water needs. Explain how active transport helps the Atlantic cod maintain homeostasis with regard to the balance of sodium and chlorine ions, which are abundant in seawater. ( Will Mark Brainliest). No Nonsense Answers. ​

Answers

Answer:

q1 : ribosomes because they are responsible for protein synthesis

q2 : by transporting potassium ions into the cell and sodium ions out of the cell maintaining a concentration gradient

q3 : seawater contains a high concentration of sodium and chlorine ions that the Atlantic cod gets rid of by actively transporting them out of its body

Which of the following best describes sickle-cell anemia?
O Caused by environmental factors that an individual was exposed to during pregnancy.
O A hereditary genetic mutation that causes a resistance to malaria.
O An inherited disorder that increases the risk of contracting malaria from mosquitos.
O A genetic mutation that is inherited from a dominant allele of one parent.

Answers

Answer: The answer should be B "O A hereditary genetic mutation that causes a resistance to malaria."

Explanation:

I do FLVS also you can find this out in your lesson 3.04 on page 5.

It says, "Sickle-cell disease is a genetic disorder that gives red blood cells a crescent shape instead of the typical disk shape. Sickle cells are stiff and sticky. They tend to block blood flow in the blood vessels of the limbs and organs. Blocked blood flow can cause pain, serious infections, and organ damage. This genetic disease is recessive, meaning the allele must be inherited from both parents to be expressed in a person’s phenotype. It is caused by a mutation in the gene that produces hemoglobin, the blood’s principle oxygen-carrying protein. Sickle-cell disease occurs more commonly in people and descendants from tropical and subtropical regions where malaria is common. Scientists have discovered that individuals with just one allele for sickle-cell disease are not only healthy, but they actually have a high resistance for the parasite that causes malaria. This resistance gives the carriers of one sickle-cell allele a great advantage over malaria, which claims more than a million lives each year, and explains why the allele for this dangerous genetic disease survives to be passed down to future generations."

Have a great day hope this helped!!!

:3

The sickle cell gene is inherited and results in sickle cell disease. You cannot catch HPV from an infected person because it is not brought on by whatever the parents did either before or during the pregnancy. Thus, option B is correct.

What are the characteristics of sickle-cell anemia?

Red blood cells are typically disc-shaped and sufficiently flexible to pass readily through blood arteries.

Red blood cells with sickle cell disease have a crescent or “sickle” shape. Because sickle cells impede blood flow to particular organs, sickle cell disease complications can develop.

The severe side effects include stroke, acute chest syndrome, organ damage, various disabilities, and even early death. Acute chest syndrome lowers the blood's oxygen content.

Therefore, A hereditary genetic mutation that causes a resistance to malaria.

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A woman has two recessive alleles, this would mean that her alleles would be:

Answers

a homeozygous pair

I hope this helps!

How do enzymes affect the reactions in living cells?

Answers

Answer:

enzymes speed up the reaction

Explanation:

Enzymes increase the rate of biochemical reactions by reducing the amount of activation energy needed for reactants to start reacting.

Answer:

Activation energy decreases.

Explanation:

The way enzymes work is by lowering the activation energy required for reactions to take place within living cells.

20 Points!

Question:
Study the illustration. The small blue spheres represent water molecules.

In which direction will water molecules move across the membrane?


Water will move from A to B.


Water will move from B to A.


There will be no net movement of water.

Answers

Given the illustration shown in the image attached to this answer, water molecules will move from B to A.

Osmosis is defined as the movement of water molecules across a semi - permeable membrane from a region of higher concentration to a region of lower concentration. Osmosis usually occurs across the cell membrane.

The cell membrane is an example of a semi - permeable membrane. Hence, water moves from B where it is at a higher concentration to A where it is at a lower concentration according to the definition of osmosis.

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This is the Bohr model for which element on the periodic table?

Answers

Answer:

The answer is Beryllium

carbon, it has 6 dots on the bohr model and it’s atomix number is 6

Immigration into an existing ecosystem will cause a population to increase if

the birth rate is greater than the death rate
the birth rate and death rate are balanced
the birth rate doubles and the death rate does not
the death rate is greater than the birth rate

Answers

Answer: A or C

Explanation: I just did it

Which type of fossil does this image depict?


A.
cast
B.
carbon imprint
C.
mineralized fossil
D.
original-tissue fossil

Answers

Answer:

this is a mineralized fossil

Explanation:

Answer:

its a cast. i took a test and got it right <3

Explanation:

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Which of the following is not a belief of the Sons of Liberty? C3H8+3O2 = 3CO2+4H2O what is the enthalpy combustion Consonance definition One hundred nautical miles equals about 185 kilometers. To the nearest kilometer, how far in kilometers is 140 nautical miles?25,900 km185 km76 km259 km Solve the system using subtraction X+4y =264x+5y=27 Please help explain how to do this with finding correct answer Name a tangent.HELPPP Convert to a mixed number and simplify: 83/6683 What is the tone of the speech from Thomas Jefferson a second inaugural address Options:A) bitterB)melodramatic C)hopefulD)serious Find mZKLM.LMKAnswer: m KLM Find the equation of the exponential function represented by the table below Gary Radio Corporation is a subsidiary of Salem Companies. Gary makes car radios that it sells to retail outlets. It purchases speakers for the radios from outside suppliers for $56 each. Recently, Salem acquired the Hyden Speaker Corporation, which makes car radio speakers that it sells to manufacturers. Hyden produces and sells approximately 200,000 speakers per year, which represents 70 percent of its operating capacity. At the present volume of activity, each speaker costs $48 to produce. This cost consists of a $32 variable cost component and an $16 fixed cost component. Hyden sells the speakers for $60 each. The managers of Gary and Hyden have been asked to consider using Hyden's excess capacity to supply Gary with some of the speakers that it currently purchases from unrelated companies. Both managers are evaluated based on return on investment. Hyden's manager suggests that the speakers be supplied at a transfer price of $60 each (the current selling price). On the other hand, Gary's manager suggests a $56 transfer price, noting that this amount covers total cost and provides Hyden a healthy contribution margin. a. What transfer price would you recommend? b. Discuss the effect of the intercompany sales on each manager's return on investment. c. Should Hyden be required to use more than excess capacity to provide speakers to Gary? In other words, should it sell to Gary some of the 200,000 units that it is currently selling to unrelated companies? Why or why not? 2. Which number is irrational?A. 319B. 93C. 419D. 94 A ranchers herd of 250 sheep grazes over a 40-acre pasture. He would like to find out how many sheep are grazing on each acre of the pasture at any given time, so he has some images of the pasture taken by the state department of agricultures aerial photography division. Here are three samples of the images.Sample 1: 4Sample 2: 1Sample 3: 9How do the sample statistics compare to the population mean and standard deviation??? Heeeeeeeeeeeelppppppp Enter the median, lower quartile, and upper quartile of the scores of 11 students on the geography quiz.82, 75, 93, 73, 71, 95, 89, 84, 72, 79, 84 What is the equation for the nth term of geometric sequence 32,48,72 Select the correct answer. Which statement about natural selection is true? A. Natural selection and evolution are two terms for the same phenomenon. B. Natural selection is an outdated theory to explain how evolution took place. C. Natural selection is the process by which organisms with more beneficial traits are more likely to survive and reproduce. D. Natural selection is the process by which organisms develop variation in traits, which gives them a better chance of survival. According to Paul, grace isa. Earnedb. Worked forc. Freely givend. A reward HELP ALMOST CLASS TIME ??? ^^