A good cancer medicine will stop cells from dividing out of control. What might be the side effects of this medicine? Explain your answer.

Answers

Answer 1
Cancer cell proliferation relies on the ability of cancer cells to grow, transition through the cell cycle, and divide. To identify novel chemical probes for dissecting the mechanisms governing cell cycle progression and cell division, and for developing new anti-cancer therapeutics, we developed and performed a novel cancer cell-based high-throughput chemical screen for cell cycle modulators. This approach identified novel G1, S, G2, and M-phase specific inhibitors with drug-like properties and diverse chemotypes likely targeting a broad array of processes. We further characterized the M-phase inhibitors and highlight the most potent M-phase inhibitor MI-181, which targets tubulin, inhibits tubulin polymerization, activates the spindle assembly checkpoint, arrests cells in mitosis, and triggers a fast apoptotic cell death. Importantly, MI-181 has broad anti-cancer activity, especially against BRAFV600E melanomas.

Related Questions

Which of the following statements are true about the esophagus? Select all that apply.
The esophagus is a bony tube.
The esophagus is a muscular tube.
The esophagus moves food from the mouth to the small intestine.
The esophagus moves food from the mouth to the stomach.
Which of the following statements are true about the esophagus?

Answers

The statements that are true about the esophagus are:

The esophagus is a muscular tube.

The esophagus is the muscular tube of the digestive tract that develops from the pharynx to the stomach.

The esophagus moves food from the mouth to the stomach.

This part of the digestive system is traversed by food, which enters through the mouth, passes through the pharynx, crosses the esophagus and reaches the stomach.

In this process, the esophagus has an active participation, since its walls contract to promote the advance of the food.

Therefore, we can conclude that the esophagus is a muscular tube that moves food from the mouth to the stomach.

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Disturbances in memory, consciousness, or identity are symptoms of:
A. affective disorders.
B. anxiety disorders.
C. dissociative disorders.
D. somatoform disorders.

Answers

dissociative disorders

Disturbances in memory, consciousness, or identity are symptoms of dissociative disorders. Thus, option C is correct.

What is wellness?

The term wellness is defined as the characteristic or quality of being in good and finer health, mental, as well as social well being. Wellness is basically being in bestest physical and mental as well as social health.There are several types of wellness which includes spiritual wellness in which people feel to sacrifice for the love of the nation, and for others too.

Emotional wellness is the main type of wellness that applies to awareing and accepting the reaction of people. Physical wellness is the type of wellness in which you are physically fit and healthy and free from diseases. Multiple disorders has been includes the affective disorders, anxiety disorders, dissociative disorders, and somatoform disorders are found in many people and these leads to serious health issues.

Therefore, Disturbances in memory, consciousness, or identity are symptoms of dissociative disorders. Thus, option C is correct.

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Can anyone help me with my homework

Answers

Answer:

Explanation:

1. True

2. True

3. False

4. False

5. False

*Earth Science* Active continental margins where the plate boundary is ocean-continent convergent are characterized by accretionary wedges.
True or false?

Answers

The correct answer is True

Explanation

An accretion wedge is an area where deformed sediment accumulates that occurs at a convergent edge at the boundaries of subduction plates (ocean-continent). This process occurs when sediments from the oceanic crust accumulate to the block of continental crust produced. by the subduction movement of the oceanic crust. So, the correct answer is True.

Helppppp Plzzzzzzz!!! 15+PTS and brainliest!!!!!

What upward force is produced by the asthenosphere?

Select one of the following.

A: Buoyant Force
B: Gravitational Force

Answers

Answer:

A: Buoyant Force

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What upward force is produced by the asthenosphere?

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Buoyant Force

Which of the following pieces of evidence does not explain how mid-ocean ridges are formed?
A. The rocks closer to the ridge are younger than those farther away.
B. Mid-ocean ridges are found on the bottom of most oceans.
C. The magnetic orientation of rocks is symmetrical on either side of mid-ocean ridges.
D. Pictures of ridges show evidence of lava flows.

Answers

Answer:

B

Explanation:

i am sorry if this is wrong

The following pieces of evidence does not mid-ocean ridges are formed Mid-ocean ridges are found on the bottom of most oceans.

What is mid-ocean ridges?

The central parts of the oceans have mid-ocean ridges. The mid-ocean ridges are volcanic underwater mountain ranges.

There is constant propelling of magma, and as the magma cools off quickly it creates new crust.

This results in the mid-ocean ridges gaining heights of up to 1.5 km above the surrounding area.

So, option B is correct.

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example of factor isolating question​

Answers

Answer:

The answer is below

Explanation:

Factor isolating question​ is a type of question often used by the researchers during a scientific study or social research which answers the question of what by isolating, categorizing, describing, or naming the situations accordingly.

For example:

What is the level of US Constitutional effectiveness in terms of

1. Public service holders performance

2. Civil servants performance

3. Private sectors

4. Effectiveness measured rate

Indicate true or false for each statement by writing the words true or false in the blanks. Certain plants contain compounds similar to ecdysone which serve as a defense against insects. Juvenile hormone levels are high in insect larvae, but must decrease in order for metamorphosis to occur. Chemicals similar to ecdysone and juvenile hormone are widely used commercially to control insect pests

Answers

Answer:

Certain plants contain compounds similar to ecdysone which serve as a defense against insects. False

Juvenile hormone levels are high in insect larvae, but must decrease in order for metamorphosis to occur. True.

Chemicals similar to ecdysone and juvenile hormone are widely used commercially to control insect pests. True

Explanation:

The plants produce toxic chemicals such as terpenoids, alkaloids, anthocyanins, phenols, and quinones as a defense against insects. Juvenile hormone levels are high in insect larvae but its concentration decrease when the insect transform into adult stage and in order to  occur metamorphosis. Ecdysone and juvenile hormone are widely used as insecticide because it prevents the insects to transform from larva to adult so if they can't mature they can't harm the plants or other things of our environment.

Drag the correct RNA bases to their matching DNA bases. Remember, guanine binds with cytosine and adenine binds with either uracil (in RNA) or thymine (in DNA).

Answers

Answer:

A-T

C-G

G-C

C-G

A-T

U-A

Explanation:

Thats how you pair RNA. Also follow GUNGAN_God#7570 on discord please.

Answer:

Hope it helps

Explanation:

(i got this one correct as you can see.)

Please rate 5 stars and give a thanks down there. you do not need an acount to do this (¬‿¬).

Which 4 body sydtems interact to allow a person to sneeze

Answers

Answer:

I think four body system is Muscular, immune, nervous, respiratory.

Explanation:

Traits or structures that likely developed from common ancestors are called _______ structures.

Answers

Answer:

I believe these are called homologous structures.

Explanation:

Homologous structures are similar to each other and likely descend from common ancestors.


Based on the data, which of the following most accurately matches a potential change with its predicted effects on the southern Florida ecosystem?

A) Introduction of a new top predator species that preys solely on Burmese pythons would cause an increase in
the raccoon population.

B) If the population of Burmese pythons were to decrease, then the cotton rat population would increase.

С) If more Burmese pythons are introduced in the Everglades, then mosquitoes will begin feeding on white-tailed deer frequently again.

D) Introduction of a new snake species that competes with the Burmese python for food would lead to an
increase in the white-tailed deer population.

Answers

Answer: A

Explanation:

Introduction of a new top predator species that preys solely on Burmese pythons would cause increase in the raccoon population (i took this test)

During composting, what happens to the initial ingredients such as eggshells, leaves, and cardboard?
A. planting
B. pollution
C. fertilization
D. decomposition

Answers

The answer is D. Decomposition

Answer:

Decomposition

Explanation:

4. Identify the compounds your cells can break down to obtain energy.

Answers

Answer:

glucose and oxygen which ultimately get transferred into ATP.

Explanation:

PLEASE HELP !! ILL GIVE 40 POINTS ; PLUS BRAINLIEST !! DONT SKIP ANSWER.

Answers

Answer:

daddy ;-0

Explanation:

Answer:

Your Answer is B

Explanation:

By burning coal and fossil fuel and  natural gas, it causes in the air

What type of plate boundary is shown in the diagram

A. Subduction boundary
B. Convergent boundary
C. Divergent boundary
D. Transform boundary​

Answers

I'll need to see a picture of the diagram to be able to answer this luv!?

Water is often referred to as a universal solvent because it can dissolve many substances. What property of water makes it such a good water?
A. Low specific heat
B. Acidity
C. Polarity
D. Lower density as liquid

Answers

Answer:

D

Explanation:


This list of characteristics describes organisms in the ________ kingdom.

Group of answer choices

protist

animal

fungi

plant

Answers

Answer:

plant

Explanation:

made a 100 good i m right

Need helpppp ASAP A student looks at a white paper through a violet filter what color will she see

Answers

The color you will see is violet

Leketa is a secret agent. She needs to send secret messages to her partner, Daniel. Leketa uses the sound waves from the beat of a drum to send her messages. Leketa and Daniel create a secret code using a pattern of drum beats to communicate with one another. In which of the following places would using a drum work to send her secret messages?
A. The drum will work on Earth, under the water, and in outer space.
B. The drum will work on Earth and under the water. The drum will not work in outer space.
C. The drum will work on Earth and in outer space. The drum will not work under the water.
D. The drum will work under the water and in outer space. The drum will not work on Earth.


Why did you choose your answer to Question 4? Explain in terms of sound waves.

Answers

Answer:

C.  The drum will work on Earth and in outer space. The drum will not work under the water.

which food groups tend to have the highest nutrient density ? Which food groups have the lowest nutrient density ? What factors contribute to Foods having high or low nutrient density ?​

Answers

Answer:

I think vegetables, fruits and dairy are the highest nutrient density, candy and different types of unhealthy food have the lowest nutrient density. It contributes to the amount of calories.

Explanation:

Remember that highest nutrient density is low calories and the lowest nutrient density is a lot of calories. There is probably no explanation about this.

I hope this answers your question! :)

Which of the following is a result of glycolysis?
a.Usage of oxygen as a strong oxidizer
b.Production of CO2
c.Conversion of FAD+ into FADH2
d.Splitting of a glucose molecule to form two G3P molecules

Answers

B. Production of co2

The main result of glycolysis is the splitting of a glucose molecule to form two G3P molecules. The Option D.

What is the main result of glycolysis?

Glycolysis, the initial step in cellular respiration involves the breakdown of glucose. One of the key outcomes of glycolysis is the splitting of a glucose molecule into two molecules of glyceraldehyde-3-phosphate (G3P).

This process occurs in the cytoplasm and does not require oxygen. Glycolysis serves as the primary source of energy production in anaerobic conditions and plays a crucial role in both aerobic and anaerobic cellular respiration.

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PLEASE HELP!! Only one of the following statements is true: Identify the true statement and explain why it is true.

a. Two organisms can be of different phylums but the same kingdom.
b. Two organisms can be of different kingdoms but the same phylum.

Answers

true Different rhythms same kingdoms

Natural selection will only lead to evolution if it allows for an organism to ________.
a. possess advantageous traits.
b. compete for resources.
c. produce offspring.
d. all of the above.

Answers

Answer:

b

Explanation:

Natural selection will  only lead to evolution if it allows for an organism to process traits, compete for resources and produce offspring. The correct option is d.

What is natural selection?

Natural selection is indeed an evolutionary mechanism. Lifeforms which are better adapted to their surroundings are much more likely to flourish and pass on the genetic traits that helped them thrive. Species change and diverge as a result of this process.

Natural selection, Darwin proposed, is a framework for evolution in which genetic variants that help support life, reproduce and survive as well as become more prevalent in a population over time.

Natural selection will occur if three conditions are met, according to Darwin's theory. These conditions, which are outlined as,

Represent a struggle for survival.Exhibit variation.Undergo inheritance.

These are the conditions that are said to be both necessary and sufficient for natural selection.

Natural selection will only result in evolution if an organism is able to process traits, compete for resources, and produce offspring.

Thus, the correct option is d.

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Slow cooling of magma produce

Answers

Answer:

The magma cools very slowly. As magma cools minerals are formed into an interlocking arrangement producing an igneous rock. As magma cools it undergoes reactions that form minerals. The rate of cooling is very important.

Explanation:

hope this helps

Draw the structures of deoxyribose, guanine, and phosphate and rate their relative solubilities in water (most soluble to least soluble). How are these solubilities consistent with the three-dimensional structure of double-stranded DNA?

Answers

Answer:

The solubilities in water of the three molecules from most to least soluble is in the following order: phosphate > deoxyribose > guanine.

Explanation:

The phosphate group is the most water-soluble due to it being very much negatively charged .

The deoxyribose which has several hydroxyl groups, is the next most water-soluble molecule.

The guanine molecule is hydrophobic, therefore, it is the least soluble in water.

A DNA molecule is composed of the three molecules: deoxyribose sugar, a phosphate group and a nitrogenous base which could either be a purine or a pyrimidine.

The three dimensional structure of DNA is such that the the phosphate groups and deodyribose sugars form the backbone of the structure on the outside of the DNA double helix where they are exposed to the aqueous environment of the nucleus. On the other hand, the hydrophobic nitrogeneous bases are located in the interior of the double helix where they are excluded from excludedthe aqueous environment of the nuclues. This structural arrangement is in accordance with the solubility of the molecules where the water-soluble phosphates and sugars are exposed to water while the water-insoluble bases are away from water.

help me or im going to fail

which one is it

Answers

Answer:

Mountains, dunes, and coast lines

I belive hope this helps :)

Answer: mountain, dunes, coastline

Explanation: :)

Which of the following are amniotes? O Birds, reptiles, and amphibians O Reptiles, birds, and dogs O Cnidarians, reptiles, and mammals O Amphibians, birds, and cnidarians​

Answers

Answer:

reptiles, birds and animals

Explanation:

amniotes are animals whose embryo develops in an amnion and chorlion and have an allanton.

they lay their eggs on land or retain them within the mother.

If the circles in the diagrams represent individual water particles, how are the positions of the particles related to the phase of matter?

Answers

Answer:

gimme ye points

Explanation:

which of these biomes has permanently forzen water in its soil? tundra chaparral savanna taiga

Answers

Answer:

these biomes has permanently frozen water in its soil is a tundra.

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